Influence of ascending noradrenergic fibers on the neurotensin-like immunoreactive neurons in the rat paraventricular nucleus |
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Authors: | F Kawakami K Fukui H Okamura T Nakajima N Yanaihara Y Ibata |
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Institution: | Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, Am Klopferspitz 18A, D-8033 Martinsried F.R.G. |
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Abstract: | The topographic organization of cells containing choline-acetyltransferase (CAT) and located within the magnocellular nuclei of the basal forebrain was studied by correlating maximum CAT decrease in one or another cortical region with a given localization of the cell lesions. Lesions were made by using ibotenic acid. Lesions affecting the ventral pallidum decreased CAT activity in the antero-medial prefrontal cortex and lesions of the internal and ventral borders of the pallidum decreased CAT activity in sensori-motor and parieto-temporal cortices. None of these lesions produced a decrease of CAT activity in the hippocampus. These results suggest that it is possible to show the presence of a specific cholinergic projection from the basal forebrain to the medial-associative prefrontal cortex of the rat. |
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Keywords: | β-endorphin dynorphin Met-enkephalin vasopressin kainic acid glutamate arcuate nucleus rat |
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