99Tcm-MDP与18F-FDG显像对转移瘤探测价值的比较

目的对恶性肿瘤患者同时行 99Tcm-MDP、 18F-FDG显像,以探索两种显像在检测转移瘤方面的能力与特点.方法对43例经病理证实的恶性肿瘤患者及1例结核患者在1个月内,分别进行 99Tcm-MDP、 18F-FDG显像.结果对骨转移瘤 99Tcm-MDP与 18F-FDG检出灵敏度、特异性、准确性分别为77%、77%,67%、91%,73%、82%. 18F-FDG对恶性肿瘤转移灶的总检出灵敏度(包括骨及骨外)为84%,较 99Tcm-MDP高出7%.结论 18F-FDG较 99Tcm-MDP对骨转移瘤更具特异性和准确性,因能发现早期骨外的软组织转移灶,故病灶隐匿者可先行 18F-FDG显像;由于二者对骨转移瘤检出灵敏度相同,且 99Tcm-MDP全身一次成像方便,故欲知有无骨转移瘤时,仍为一种准确经济的好方法.

Comparison of 99Tcm-

Objective To compare the ability of detecting metastases for two methods, the patients who illed with malignant tumor underwent examinations of ~(99)Tc~m-MDP (technetium-99m methylene diphosphate) and ~(18)F-FDG (~(18)F-fluoro-2-deoxy-D-glucose) imaging during a month. Methods Forty-three patients with malignant tumor and a tuberculosis patient that were confirmed by pathology underwent examination of ~(99)Tc~m-MDP and ~(18)F-FDG imaging. Results The sensitivity, specificity and accuracy for ~(99)Tc~m-MDP and ~(18)F-FDG imaging were 77% and 77%, 67% and 91%, 73% and 82% to detect the bone metastases respectively. But total sensitivity (including bone and out of bone) was 84% for ~(18)F-FDG imaging. It was 7% higher than ~(99)Tc~m-MDP. Conclusion ~(18)F-FDG examination should be adopted earlier if there is some information to suggest malignant tumor but focus to occult. Because ~(99)Tc~m-MDP imaging may have whole body bone scan in one time and may discover bone metastases sensitively and economically, so that is a good method for patient who doubted bone metastases.