原发性中枢神经系统恶性淋巴瘤临床病理分析

目的：探讨原发性中枢神经系统恶性肿瘤的临床病理特点、诊断及鉴别诊断。方法：对10例原发性中枢神经系统恶性淋巴瘤进行临床资料分析及光镜和免疫组化研究。结果：临床上以颅内压高为主要症状,组织学特征：瘤细胞单一、异型、围绕血管呈套袖样排列,无滤泡形成；免疫组化：LCA、CD20或CD43阳性,CK、GFAP阴性,提示多为B细胞性。结论：原发性中枢神经系统恶性淋巴瘤有其独特的临床病理特点,需与其他颅内小圆形细胞肿瘤鉴别,光镜结合免疫组化染色可以确诊。

Clinicopathological Analysis of Primary Malignant Lymphoma in Central Nervous System

Objective: To explore the clinicopathological feature,diagnosis and differential diagnosis of the primary central nervous system malignant lymphoma(PCNS-ML).Methods: The clinical data of 10 patients with PCNS-ML were analyzed retrospectively.Their pathology was studied by light microscope and immunohistochemistry in which monoclona.Histologically,the LCA,CD20,CD43,CK and GFAP were used.Results: The main symptoms were caused by intracranisl hypertension.Histologically,the tumor cells were heteromophic and spreaded around the vessels,and no follicles were formed in the PCNS-ML.The immunohistochemical examination showed that in all the tumor cells LCA,and CD20 or CD43 were positive,and CK,GFAP were negative.It was suggested that most of the PCNS-ML were derived from B cells.Conclusions: The PCNS-ML has the distinct clinicopathological features.The differential diagnosis should be made between this tumor and the other intracranial tumors of small and round cells.Its diagnosis mainly relies on light microscope and immunohistochemistry examination.