| PD-1及其配体PD-L1/PD-L2在寄生虫感染免疫中的作用 |
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| 引用本文： | 李颖,夏超明.PD-1及其配体PD-L1/PD-L2在寄生虫感染免疫中的作用[J].国际医学寄生虫病杂志,2006,33(1):53-56. |
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| 作者姓名： | 李颖 夏超明 |
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| 作者单位： | 215000,苏州,苏州大学基础医学系寄生虫教研室 |
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| 摘 要： | 程序性死亡-1(programmed death1,PD-1)及其配体PD-L1(ligand1of programmed death-1)/PD-L2(ligand2of programmed death-1)是继CTLA-4/CD28后发现的B7/CD28家族分子,能负调控T细胞的活化和细胞因子的分泌,在寄生虫感染免疫、肿瘤免疫和自身免疫性疾病中有重要的临床应用前景。该文对PD-1的生物学特点及其与配体的作用途径等进行综述。
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| 关 键 词： | PD-1 感染免疫 寄生虫感染 |
| 修稿时间： | 2005年10月24 |
The role of PD-1 and it's ligand PD-L1/PD-L2 in the parasitic infection immune |
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| LI Ying,XIA Chao-ming.The role of PD-1 and it''''s ligand PD-L1/PD-L2 in the parasitic infection immune[J].International JOurnal of Medical Parasitic Diseases,2006,33(1):53-56. |
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| Authors: | LI Ying XIA Chao-ming |
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| Abstract: | Programmed death 1(PD-1)and it's ligand, PD-L1 or PD-L2 are members of B7/CD28 family. They can negatively modulate the activation of T cells and the production of cytokines. PD-1 and PD-L1/PD-L2 play an important role in parasite immunology, tumor immunology and autoimmune diseases. This article overviews biological characteristics and functions of PD-1 and PD-L. |
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| Keywords: | PD-1 Infection immunity Parasitic infection |
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