寻常型天疱疮血清白介素-1、白介素-10、肿瘤坏死因子-α的检测

目的：探讨白介素-1（IL-1）、白介素-IO（IL-10）、肿瘤坏死因子-ot（TNF—d）在寻常型天疱疮（PV）发病机制中的作用。方法：采用ELISA方法检测32例PV患者活动期和缓解期血清IL-1、IL-10、TNF-α水平。结果：PV患者活动期血清IL-1、TNF-α较对照组明显升高（P〈0．01），缓解期与对照组相比差异无统计学意义（P〉0.05）；活动期血清IL-10较对照组降低（P〈0．01），缓解期与对照组相比差异无统计学意义（P〉0．05）。结论：IL-1、IL-10及TNF-α在PV发病中起了重要的作用。

Study on level of Interleukin-1、Interleukin-10、Tumour necrosis factor-αin the patients with pemphigus vulgaris

Objective：To investigate the pathogenetic role of IL-1 ,IL-10,TNF-α in the patients with pemphigus vulgaris. Methods：Level of IL-1 ,IL-IO and TNF-α in serum of thirty-two patients with pemphigus vulgaris in active stage and inactive stage were detected by enzyme-linked immunosorbert assays. Results： IL-1 and TNF-α in serum of pemphigus vulgaris patients in active stage were significantly higher than those in healthy control subjects （P〈0.01）,and IL-1 and TNF-α in serum of pemphigus vulgaris patients in inactive stage were only slight higher than those in healthy control subjects （P〉 0.05）. IL-10 in serum of pemphigus vulgaris patients in active stage was significantly lower than that in healthy control subjects（P〈0.01）,and IL-10 in serum of pemphigns vulgaris patients in inactive stage was only slight lower than that in healthy control subjects （P〉0.05）. Conclusion：These results suggest that IL-1 ,IL-10 and TNF-α demonstrates an association with disease activity.