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| 同种异体成骨细胞移植的免疫学研究 | |
| 引用本文： | 王小勇,席庆,付振虹,毛天球,曹罡.同种异体成骨细胞移植的免疫学研究[J].中国组织工程研究与临床康复,2003,7(2):222-223. |
| 作者姓名： | 王小勇 席庆 付振虹 毛天球 曹罡 |
| 作者单位： | 1. 解放军军事科学院门诊部口腔科,北京市 100091 2. 解放军第四军医大学口腔医院颌面外科, 陕西省西安市 710032 3. 解放军总医院心脏内科,北京市 100080 |
| 基金项目： | 全军“十五”重点课题(01Z089) |
| 摘 要： | 目的:组织工程骨移植的排斥反应将主要取决于成骨细胞的抗原成分,对不同种系成骨细胞植入后体液免疫水平进行检测,探讨组织工程骨组织植入体内后可能的免疫排斥机制,并为应用于工程骨的种子细胞寻找可靠的种系来源。方法:行成骨细胞同胎、间种异体、同种异基因及自体细胞腹直肌袋内移植,分别于术后1,2,4,8周行免疫学及组织形态学检测。结果:各组动物在移植后一两周内均可检测到特异性抗体,同种异基因移植组持续时间最久,异基因组组织学指标高于同种异体组。结论:自体、同胎及同种异体或同种异基因细胞均可作为组织工程骨移植可靠的细胞来源。 |
| 关 键 词： | 成骨细胞 移植 移植免疫学 |
| 文章编号： | 1671-5926(2003)02-0222-02 |
| 修稿时间： | 2002年8月29日 |
Immunological research of osteoblast allotransplan-tation |
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| Wang Xiaoyong,Xi Qing,Fu Zhenhong,Mao Tianqiu,Cao Gang Wang Xiaoyong,Oral.Immunological research of osteoblast allotransplan-tation[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2003,7(2):222-223. | |
| Authors: | Wang Xiaoyong Xi Qing Fu Zhenhong Mao Tianqiu Cao Gang Wang Xiaoyong Oral |
| Institution: | Wang Xiaoyong,Xi Qing,Fu Zhenhong,Mao Tianqiu,Cao Gang Wang Xiaoyong,Oral Department of Academy of Military Science,Beijing 100091,China X! Qing,Mao Tianqiu,Cao Gang,Oral Maxillafacial Department of Stomatological Hospital of Fourth Military Medical University,Xi' an 710032,Shanxi Province,China Fu Zhenhong,Department of Cardiovasology of General Hospital of PLA,Beijing 100080,China |
| Abstract: | AIM: To detect the immunity of different stirps oateoblast transplantation, and to discuss the potential immunological mechanism and find the allogeneic cell source of tissue-engineered-bone. METHODS: Osteoblast of the same venter, isogeneic, allogeneic and autogenetic sources were transplanted into the rectus abdominus muscle of the each rabbit. Immunological tests and histological observation were performed 1, 2, 4 and 8 weeks following transplantation. BESULTS: A specific antibody reaction was detected in all groups one to two weeks after transplantation, and heterogeneity group persisted the longest time. CONCLUSION: Same venter, isogeneic, allogeneic and autogenetic osteoblast can be the reliable cell source for tissue engineered bone, heterogeneity cell need to be processed before using in tissue engineering. |
| Keywords: | osteoblasts transplantation transplantation immunology |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |