| 咖啡酸酯对持续脑缺血大鼠神经细胞凋亡指标的影响 |
| |
| 引用本文： | 付学军,褚晓凡,张莹,刘艳. 咖啡酸酯对持续脑缺血大鼠神经细胞凋亡指标的影响[J]. 中国医疗前沿, 2011, 6(8): 28-29,14 |
| |
| 作者姓名： | 付学军 褚晓凡 张莹 刘艳 |
| |
| 作者单位： | 暨南大学第二附属医院、广东省深圳市人民医院神经内科,518020 |
| |
| 基金项目： | 深圳市科技计划项目基金资助 |
| |
| 摘 要： | 目的观察咖啡酸酯对大鼠持续缺血模型大脑顶叶神经细胞凋亡的影响。方法选用SD雄性大鼠110只,随机分为空白组、对照组、药物组,各组根据缺血时间不同再分为持续缺血3h、6h、12h、24h和48h亚组,采用颈内动脉线栓加环扎法复制大鼠持续脑缺血模型,建立大鼠持续脑缺血神经细胞凋亡模型,造模后腹腔注射相应药物。将各组大鼠的存活率、组织学改变以及TUNEL表达、Caspase-3蛋白表达情况作为主要观察指标。结果 12、24h和48h对照组和给药组存活率相比存在统计学意义,12h、24h、48h评分组间相比,差异均存在显著性,组织学结果显示给药组神经细胞损伤程度较对照组为轻,受损细胞数少于对照组。6、12、24、48h给药组海马区凋亡细胞明显少于对照组,caspase-3蛋白明显少于对照组。结论咖啡酸酯可以抑制Caspase-3蛋白表达。
|
| 关 键 词： | 咖啡酸酯 大鼠 凋亡 Caspase-3 |
The Influence of Caffeic Acid Ester on Apoptosis Index of Neuron on Persistent Ischemia Rats |
| |
| FU Xue-jun,CHU Xiao-fan,ZHANG Ying,et al.. The Influence of Caffeic Acid Ester on Apoptosis Index of Neuron on Persistent Ischemia Rats[J]. China Healthcare Innovation, 2011, 6(8): 28-29,14 |
| |
| Authors: | FU Xue-jun CHU Xiao-fan ZHANG Ying et al. |
| |
| Affiliation: | FU Xue-jun,CHU Xiao-fan,ZHANG Ying,et al.The People's Hospital of Shenzhen,The Second Affiliated Hospital of Jinan University,Shenzhen 518020,China |
| |
| Abstract: | Objective To investigate the influence of Caffeic Acid Ester administration on neuron cells of frontal lobe of rats during the whole process of Middle Cerebral Artery Occlusion(MCAo) the index of apoptosis.Methods 110 male SD rats were selected and randomly divided into 3 groups which are sham-opteration group,control group and medicine group.The animal model of focal cerebral ischemia was established by nylon suture embolization and cerclage.2% Caffeic Acid Ester were injected into the abdominal cavity of ... |
| |
| Keywords: | Caspase-3 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
