氟比洛芬酯超前镇痛用于小儿扁桃体联合腺样体切除术的临床观察

目的探讨在小儿扁桃体联合腺样体切除术前静注氟比洛芬酯超前镇痛的安全性、有效性及最佳剂量。方法 60例择期行扁桃体联合腺样体切除术患儿随机均分为三组,分别在麻醉诱导时静注生理盐水10ml（F0）、氟比洛芬酯1mg/kg（F1组）、氟比洛芬酯1.5mg/kg（F2组）。观察术中及术后0.5、1、4、8、12、24h（T1-6）的HR、MAP、RR、SPO2,术后各时间点的VASF评分值及不良反应。结果三组术中HR、MAP和术后RR、SpO2均无显著差异。F1组MAP、HR在T1、T2低于F0组（P〈0.05）;F2组MAP、HR在T1-3低于F0组而HR在T4仍低于F0组（P〈0.05）;F1组与F2组间比较无显著性差异。术后VASF评分三组患儿在4h以内最高,以后呈下降趋势;F1组在T1-3显著低于F0组（P〈0.01,P〈0.05）;F2组T1-3和T4、T5显著低于F0组（P〈0.01,P〈0.05）,在T1-4低于F1组（P〈0.05）。术后躁动发生率F0组为50%,F2组显著低于F0、F1组（P〈0.01,P〈0.05）;F2组拔管后哭闹的发生率低于F0组（P〈0.05）。结论小儿扁桃体联合腺样体切除术前静注氟比洛芬酯1-1.5mg/kg均可产生良好的超前镇痛效果,不良反应少,1.5mg/kg效果更优。

The clinical observation of the apply of preemptive analgesia of flurbiprofen axetil injection on children tonsilloadenoidectomy

Objective To observe the safety,effecacy and the best dosage of prremptive analgesia of flurbiprofen axetil on children tonsilloadenoidectomy.Methods Sixty patients were randomly divided into three groups with 20 cases each: normanl saline 10ml(group F0),flurbiprofen axetil 1mg/kg(group F1),flurbiprofen axetil 1.5mg/kg(group F2) were injected during anesthesia introduction separatly.Observing HR,MAP,RR,SPO2 during intro-and post-operative.Post-operative VASF scores and side effects were recorded at 0.5,1,4,...