| 人参皂甙Rg3治疗子宫内膜异位症模型大鼠后VEGF、MVD的变化 |
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| 引用本文： | 陈韶慧,李兆艾.人参皂甙Rg3治疗子宫内膜异位症模型大鼠后VEGF、MVD的变化[J].中国医疗前沿,2011,6(8):26-27,64. |
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| 作者姓名： | 陈韶慧 李兆艾 |
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| 作者单位： | 山西省妇幼保健院,太原,030013 |
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| 基金项目： | 山西省卫生厅科技攻关基金资助项目 |
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| 摘 要： | 目的探讨人参皂甙Rg3治疗大鼠子宫内膜异位症（EMs）模型后,不同时期异位病灶体积的变化及血清中抗血管生成因子（VEGF）及异位组织微血管密度（MVD）数量的影响,进一步观察药物的治疗效果。方法参照Jones方法建立Wistar大鼠EMs动物模型,3周后将建模成功的大鼠随机分为空白对照组、人参皂甙Rg3照组、孕三烯酮组,每组20只,观察不同时期异位囊肿体积的变化,ELISA法检测不同时期血清中VEGF变化;免疫组化PV法,通过CD31标记异位子宫内膜血管,测定其微血管密度（MVD）。结果治疗后,用药组异位病灶体积与对照组体积比较,P〈0.05,各给药组血清中VEGF表达、组织中MVD数量均低于对照组,P〈0.05,其中人参皂甙组较为明显。停药8周后,用药组异位病灶体积进一步萎缩与对照组体积比较,P〈0.05,与用药后比较,P〈0.05,各给药组血清中VEGF表达、组织中MVD数量均低于对照组,P〈0.05。结论人参皂甙Rg3治疗子宫内膜异位症抗血管生成作用明显,对异位病灶有较强的抑制作用,能降低复发率。
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| 关 键 词： | 人参皂甙Rg3 子宫内膜异位症 血管内皮生长因子 微血管密度 血管生长 |
The change of vascular endothelial growth factor(VEGF)and microvessel density(MVD) after ginsenoside Rg3 treated endometriosis models of rats |
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| CHEN Shao-hui,LI Zhao-ai.The change of vascular endothelial growth factor(VEGF)and microvessel density(MVD) after ginsenoside Rg3 treated endometriosis models of rats[J].China Healthcare Innovation,2011,6(8):26-27,64. |
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| Authors: | CHEN Shao-hui LI Zhao-ai |
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| Institution: | CHEN Shao-hui,LI Zhao-ai.Department of the Obstetrics & Gynecology,Women and Children Hospital of Shanxi Province,Taiyuan 030013,China |
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| Abstract: | Objective To observe the change of vascular endothelial growth factor(VEGF) and microvessel density(MVD) after ginsenoside Rg3 treated endometriosis models of rats,Further observation the therapeutic effect of drugs.Methods The endometriosis model was established in Wistar rats and the model rat s were divided into 3 groups that were treated with normal saline(control),ginsenoside Rg3 and gestrinone,20 rats in every group.respectively After 8 weeks of treatment,ectopic endometrium grafts were examined for t... |
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| Keywords: | GinsenosideRg3 Endometriosis Vascular endothelial growth factor Microvesseldensity Angiogenesis |
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