| 正交试验优选乳酸左氧氟沙星葡萄糖注射液的制备工艺 |
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| 引用本文： | 张广求,张美祥.正交试验优选乳酸左氧氟沙星葡萄糖注射液的制备工艺[J].中国药房,2005,16(19):1463-1464. |
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| 作者姓名： | 张广求 张美祥 |
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| 作者单位： | 湖北黄冈市第一人民医院药剂科 黄冈市438000
(张广求)，湖北黄冈市第一人民医院药剂科 黄冈市438000(张美祥) |
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| 摘 要： | 目的:优选乳酸左氧氟沙星葡萄糖注射液的制备工艺。方法:采用正交试验法,选用L16(45)正交表进行试验,考察pH值、加炭量、加热温度和加热时间4因素对乳酸左氧氟沙星含量的影响。结果:确定最佳制备工艺条件为pH=4.2～4.8、加炭量0.1%、加热温度50℃、加热时间10min。结论:按该工艺制备的成品质量符合要求。
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| 关 键 词： | 乳酸左氧氟沙星葡萄糖注射液 制备工艺 正交试验 |
| 文章编号： | 1001-0408（2005）19-1463-02 |
| 收稿时间： | 2004-12-01 |
| 修稿时间： | 2005-01-17 |
Optimize Preparation Technique of Levofloxacin Lactate and Glucose Injection by Orthogonal Test |
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| Zhang GuangQiu;Zhang MeiXiang.Optimize Preparation Technique of Levofloxacin Lactate and Glucose Injection by Orthogonal Test[J].China Pharmacy,2005,16(19):1463-1464. |
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| Authors: | Zhang GuangQiu;Zhang MeiXiang |
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| Abstract: | OBJECTIVE:To optimize the preparation technique of levofoxacin lactate and glucose injection.METHODS:Orthogonal test was applied in which orthogonal table L 16 (4 5 )was chosen to perform the experiment.The effects of4factors,i.e.the pH value,amount of activated carbon added,temperature of heating and time of heating on the content of levofloxacin lactate was investigated.RESULTS:The optimum preparation technical conditions were turned out to be the following:the pH value was4.2～4.8,the amount of activated carbon was0.1%,the heating temperature was50℃with10min of heating time.CONCLUSION:The quality of the finished products from this preparation technique was in line with quality requirement. |
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| Keywords: | Levofloxacin lactate and glucose injection Preparation technique Orthogonal test |
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