| 肌浆网释放Ca2+对心房钠尿肽分泌的影响 |
| |
| 引用本文： | 华树东,刘洋,洪兰,金元哲,崔勋.肌浆网释放Ca2+对心房钠尿肽分泌的影响[J].中国现代医学杂志,2008,18(21). |
| |
| 作者姓名： | 华树东 刘洋 洪兰 金元哲 崔勋 |
| |
| 作者单位： | 1. 延边大学,基础医学院,生理学与病理生理学教研部,吉林,延吉,133000
2. 延边大学,基础医学院,生理学与病理生理学教研部,吉林,延吉,133000;延边大学,长白山功能因子省部共建重点实验室,吉林,延吉,133000 |
| |
| 基金项目： | 国家自然科学基金资助(No:30260033) |
| |
| 摘 要： | 目的 观察肌浆网(sarcoplasmic reticulum,SR)释放Ca2+对心房钠尿肽(atrial natriuretic peptide,ANP)分泌的影响.方法 利用SR激活剂和阻断剂,采用搏动的离体心房灌流模型及放射免疫技术观察SR释放Ca2+对家兔心房ANP分泌的变化.结果 SR抑制剂Ryanodine明显促使心房ANP的分泌,同时显著抑制心房搏出量和心房搏动压,而SR激活剂咖啡因的作用与Ryanodine完全相反.心肌兴奋-收缩耦联脱敏剂2,3-丁二酮单肟(BDM)促使ANP的分泌,对心房搏出量和心房搏动压呈抑制效应.腺苷酸环化酶直接激活剂福司柯林明显抑制ANP分泌,同时显著增加cAMP逸出量和心房搏出量.阻断L-型Ca2+通道明显促进心房ANP的分泌,但未能改变咖啡因对ANP分泌的抑制效应.结论 阻断SK或L-型Ca2+通道使细胞内Ca2+浓度降低可促进ANP的分泌,而激活二者则抑制ANP分泌.
|
| 关 键 词： | 心房钠尿肽 肌浆网 Ca2+ Ryanodine 咖啡因 |
Effects of Ca~(2+) released from sarcoplasmic reticulum on atrial natriuretic peptide secretion in rabbit atria |
| |
| HUA Shu-dong
,
LIU Yang
,
HONG Lan
,
JIN Yuan-Zhe
,
CUI Xun.Effects of Ca~(2+) released from sarcoplasmic reticulum on atrial natriuretic peptide secretion in rabbit atria[J].China Journal of Modern Medicine,2008,18(21). |
| |
| Authors: | HUA Shu-dong LIU Yang HONG Lan JIN Yuan-Zhe CUI Xun |
| |
| Institution: | HUA Shu-dong1,LIU Yang1,HONG Lan1,JIN Yuan-Zhe1,2,CUI Xun1,2(1.Department of Physiology , Pathophysiology,College of Basic Medicine,2.Key Laboratory of Organism Function Functional Factors of the Changbai Mountain,Ministry of Eduction,Yanbian University,Yanji,Jilin 133000,P.R.China) |
| |
| Abstract: | Objective To investigate the effects of Ca2+released from sarcoplasmic reticulum on atrial natriuretic peptide(ANP) secretion.MethodsExperiments have been done in isolated perfused beating left rabbit atria.ANP was measured by radioimmunoassay in the atrial perfusate in real-time base.ResultsRyanodine, Ca2+ transport blocker, increased atrial ANP secretion concomitantly with decreased atrial stroke volume and pulse pressure.Caffeine, an activator of sarcoplasmic reticulum, inhibited ANP secretion with incre... |
| |
| Keywords: | atrial natriuretic peptide sarcoplasmic reticulum calcium ryanodine caffeine |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
