| 药物后适应对急性心肌梗死心肌保护作用的临床研究 |
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| 引用本文： | 张国明,王禹,李天德,陈练,孙志军,王峙峰,沈洪,苏绍萍.药物后适应对急性心肌梗死心肌保护作用的临床研究[J].军医进修学院学报,2009,30(4):460-461. |
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| 作者姓名： | 张国明 王禹 李天德 陈练 孙志军 王峙峰 沈洪 苏绍萍 |
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| 作者单位： | 1. 解放军总医院心血管内科,北京心血管内科,100853
2. 解放军总医院急诊科,北京,100853 |
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| 基金项目： | 解放军总医院科技创新基金 |
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| 摘 要： | 目的探讨硝酸甘油和地尔硫卓药物后适应对急性ST段抬高型心肌梗死患者的心肌保护作用。方法比较2003年1月-2007年12月在我中心接受急诊PCI的310例STEMI患者，根据是否给予硝酸甘油＋地尔硫卓药物后适应分为药物后适应组（152例）和对照组（158例）。结果术后即刻药物后适应组cTFC值较低，MBG分级高。药物后适应组的术后12h ST段回落幅度较大，术后5d血清肌酸激酶同工酶曲线下面积较小，心脏超声左心室射血分数较高。另两组随访期间死亡比例和因心脏原因再次住院次数均差异显著。结论在急性ST段抬高型心肌梗死中联合注射硝酸甘油和地尔硫卓进行药物后适应可显著改善再通后心肌的微灌注，减少近期死亡等主要心血管病事件的发生。
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| 关 键 词： | 心肌梗死 药物后适应 硝酸甘油 地尔硫卓 |
Effect of pharmacological postconditioning on acute myocardial infarction |
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| ZHANG Guo-ming,WANG Yu,LI Tian-de,CHEN Lian,SUN Zhi-jun,WANG Zhi-feng,SHEN Hong,SU Shao-ping.Effect of pharmacological postconditioning on acute myocardial infarction[J].Academic Journal of Pla Postgraduate Medical School,2009,30(4):460-461. |
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| Authors: | ZHANG Guo-ming WANG Yu LI Tian-de CHEN Lian SUN Zhi-jun WANG Zhi-feng SHEN Hong SU Shao-ping |
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| Institution: | ZHANG Guo-ming1,WANG Yu1,LI Tian-de1,CHEN Lian1,SUN Zhi-jun1,WANG Zhi-feng1,SHEN Hong2,SU Shao-ping1 1Cardiovascular Department,2Emergency Department Chinese PLA General Hospital,Beijing 100853,China |
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| Abstract: | Objective To study the effect of pharmacological postconditioning of nitroglycerin and diltiazem on ST elevated myocardial infarction(STEMI) . MethodsThis study was conducted in 310 patients with STEMI undergoing emergency PCI in our center from January of 2003 to December of 2007. The enrolled patients were randomly assigned to receive pharmacological postconditioning of nitroglycerin with diltiazem(152) or receive none of them(158) . ResultsIn pharmacological postconditioning group,the corrected TIMI fram... |
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| Keywords: | myocardial infarction pharmacological postconditioning nitroglycerin diltiazem |
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