紫花前胡化学成分的研究

目的研究中药紫花前胡［Peucedanum decursivum(Miq.)Maxim］根的化学成分。方法用硅胶柱色谱和制备型高效液相色谱进行分离纯化，用光谱分析和化学方法鉴定其结构。结果从紫花前胡根中分得7个线型吡喃香豆素类化合物，其结构分别鉴定为3′(S)-hydroxy-4′(R)-angeloyloxy-3′,4′-dihydroxanthyletin(1);3′(S)-acetoxy-4′(R)-hydroxy-3′,4′-dihydroxanthyletin(2);3′(S)-acetoxy-4′(R)-angeloyloxy-3′,4′-dihydroxanthyletin(3);Pd-C-IV(4);Pd-C-II(5);(+)-3′S-Decursinol(6);(+)-trans-Decursidinol(7)。结论化合物1和2为新化合物，分别命名为紫花前胡素D和紫花前胡素F;6和7为首次从该植物中分得。

CHEMICAL CONSTITUENTS OF PEUCEDANUM DECURSIVUM

AIM: To study the chemical constituents of Peucedanum decursivum. METHODS: Various column chromatographies with silica gel and HPLC were employed for the isolation and purification. The structures of the compounds were elucidated on basis of spectral analyses and chemical methods. RESULTS: Seven compounds were isolated from the roots of Peucedanum decursivum (Miq.) Maxim. 1 is 3'(S)-hydroxy-4' (R)-angeloyloxy-3',4'-dihydroxanthyletin, named Decursitin D; 2 is 3'(S)-acetoxy-4'(R)-hydroxy-3',4'-dihydroxanthyletin, named decurstin F; the others are 3'(S)-acetoxy-4'(R)-angeloyloxy-3', 4'-dihydroxanthyletin (3), Pd-C-IV (4), Pd-C-II (5), (+)-3'S-decursinol (6) and (+)-trans-decursidinol (7). CONCLUSION: Compounds 1 and 2 are new compounds, while compounds 6 and 7 were isolated from Peucedanum decursivum (Miq.) Maxim for the first time.