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灯盏花中新的酚酸类化合物的结构及活性研究
引用本文:张卫东,陈万生,HA.Thi Bang Tam,孔德云,李惠庭,王永红.灯盏花中新的酚酸类化合物的结构及活性研究[J].药学学报,2001,36(5):360-363.
作者姓名:张卫东  陈万生  HA.Thi Bang Tam  孔德云  李惠庭  王永红
作者单位:1. 第二军医大学药学院
2. 法国图卢兹大学药学院
3. 上海医药工业研究院
基金项目:国家自然科学基金资助项目!(2 9972 0 5 4)
摘    要:目的研究中药灯盏花[Erigeron breviscapus (Vant.)Hand-Mazz]的心血管活性成分。方法用各种色谱技术进行分离,用IR,UV,MS,1HNMR,13CNMR,2DNMR光谱鉴定他们的结构。以乳酸脱氢酶(LDH)释放量为指标测定BCMEC(bovinecerebralmicrovascularendothelialcell)损伤,比色法测定药物体外抗氧化和抗活性氧能力。结果从灯盏花中分离得到2个化合物,分别鉴定化合物的结构为:1-O-甲基-3,5-O-双咖啡酰基奎宁酸甲酯(III)和5-O-咖啡酰基奎宁酸丁酯(IV)。结论化合物III,IV为新的酚酸类化合物,化合物III对LPC引起的BCMEC损伤有明显的保护作用。

关 键 词:灯盏花  化学成分  酚酸类
收稿时间:2000-10-12

STUDY ON THE STRUCTURE AND ACTIVITY OF NEW PHENOLIC ACID COMPOUNDS FROM ERIGERON BREVISCAPUS
ZHANG Wei-dong,CHEN Wan-sheng,HA.Thi Bang Tam,Isabella FOURASTE,KONG De-yun,LI Hui-ting,WANG Yong-hong.STUDY ON THE STRUCTURE AND ACTIVITY OF NEW PHENOLIC ACID COMPOUNDS FROM ERIGERON BREVISCAPUS[J].Acta Pharmaceutica Sinica,2001,36(5):360-363.
Authors:ZHANG Wei-dong  CHEN Wan-sheng  HAThi Bang Tam  Isabella FOURASTE  KONG De-yun  LI Hui-ting  WANG Yong-hong
Institution:Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Abstract:AIM To isolate and identify the active constituents of Erigeron brevisapus (Vant.) Hand. Mazz. METHODS The chemical constituents were isolated by silica gel column chromatography and two new compounds were obtained. Their structures were elucidated by IR, MS, 1HNMR , 13 CNMR , DEPT and 2DNMR. The injury of BCMEC (bovine cerebral microvascular endothelial cell) was determined by lactic dehydrogenase (LDH), the ability of the drugs anti oxidation and scavenging oxidation of free radical was measured by colorimetric method. RESULTS Two new compounds have been identified as 1 O methyl 3, 5 O dicaffeoyl quinic acid methyl ester (III) and 5 O caffeoyl quinic acid butyl ester (IV). CONCLUSION Compounds III and IV are new compounds. Compound III can protect BCMEC injury by LPC.
Keywords:Erigeron brevisapus  composite  phenolic acid
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