Detection and characterization of neurotoxicity in cancer patients using proton MR spectroscopy |
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Authors: | Emilie A. Steffen-Smith Pamela L. Wolters Paul S. Albert Eva H. Baker Kim C. Shimoda Alan S. Barnett Katherine E. Warren |
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Affiliation: | Pediatric Oncology Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health (NIH), Bethesda, MD, USA. |
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Abstract: | OBJECTIVE: The study objective was to detect abnormalities and identify relationships between brain metabolic ratios determined by proton magnetic resonance spectroscopic imaging ((1)H-MRSI) and neuropsychological (NP) function in cancer patients at risk for neurotoxicity. METHODS: Thirty-two patients received (1)H-MRSI using a multi-slice, multi-voxel technique on a 1.5T magnet. Cho/NAA, NAA/Cr, and Cho/Cr ratios were identified in seven pre-determined sites without tumor involvement. A battery of age-appropriate NP tests was administered within 7 days of imaging. Relationships were examined between test scores and metabolite ratios. CONCLUSIONS: This study identifies relationships between brain metabolite ratios and cognitive functioning in cancer patients. (1)H-MRSI may be useful in early detection of neurotoxic effects, but prospective longitudinal studies in a homogeneous population are recommended to determine the prognostic value. |
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Keywords: | MRI MRS Primary brain tumor Pediatric Neuropsychological assessment |
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