脓毒症并多器官功能障碍综合征的血脂分析与预后关系的探讨

目的探讨血脂在脓毒症并多器官功能障碍综合征(multipleorgandysfunctionsyn-drom,MODS)患儿血中的变化及与预后的关系。方法选择符合诊断标准的34例脓毒症并MODS的患儿(其中最后存活22例,死亡12例)作为脓毒症组,检测确定诊断后第2天晨起空腹血的血脂水平,并选择同一时期同一年龄组健康体检者15例,测血脂水平做为对照,进行前瞻性研究。结果存活者与死亡者的血清胆固醇(总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)相比差异有显著性(P<0·01),死亡者有较低浓度的血胆固醇水平;脓毒症组与对照组的血清胆固醇(总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)相比差异有显著性(P<0·01),脓毒症组有较低浓度的血胆固醇水平,而血甘油三酯无显著性差异。结论脓毒症并MODS患儿的血胆固醇(总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)水平与预后有关,血胆固醇(总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)越低,预后越差。

Clinical analysis on the serum cholesterol and mortality in septic children with multiple organ dysfunction syndrome

Objective To investigate the relationship between serum cholesterol and mortality in septic children with multiple organ dysfunction syndrome (MODS).Methods The 34 septic children with MODS were chosen for study (22 cases survived and 12 cases died) and 15 healthy children were selected as control.Serum cholesterol was measured on the next morning after admission. Results Survivors had significantlyhigher serum cholesterol(total cholesterol,low density lipoprotein,high density lipoprotein) as compared to nonsurvivors (P<0.01).Septic children with MODS had lower serum cholesterol as compared to controls.Circulating triglyceride level did not differ significantly between survivors and nonsurvivors or between septic children with MODS and controls.Conclusion The serum cholesterol panel (total cholesterol,low density lipoprotein,high density lipoprotein) is related to mortality of septic children with MODS.