喹诺酮类药物致过敏性休克165例文献分析

目的探讨喹诺酮类药物致过敏性休克的一般规律及特点。方法对近10年国内文献报道的有关喹诺酮类药物致过敏性休克165例进行分类统计、分析。结果致过敏性休克涉及10种药物,环丙沙星、氧氟沙星和诺氟沙星分别位居前3位,占总例数的69.70%;以静脉方式给药的发生率最高,占总例数的64.85%;主要发生于用药30min内,其占总例数的70.30%;致死病例占总例数的2.42%。结论临床应重视喹诺酮类药物的严重不良反应,以确保用药安全。

Quinolones-induced Allergic Shock: Literature Review of 165 Cases

OBJECTIVE:To discuss the general pattern and the characteristics of quinolones-induced allergic shocks.ME_THODS:A total of 165 quinolones-induced allergic shock cases reported in the domestic periodicals in recent 10 years were statistically classified and analyzed.RESULTS:Ten kinds of quinolones involved allergy shocks with ciprofloxacin,ofloxacin and norfloxacin respectively dominated the first 3 places,which account for 69.70% of the total.The incidence of allergy shocks was the highest when used intravenously(64.85%),in particular within the first 30min(70.30%) with the mortality at 2.42%.CO_NCLUSION:Attention should be paid to severe adverse drug reactions in the clinic so as to ensure safe drug use.