Importance of mast cells in the pathophysiology of asthma |
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| Authors: | Seong H Cho Andrea J Anderson Chad K Oh |
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| Institution: | (1) Division of Allergy and Immunology, Department of Pediatrics, Harbor-UCLA Medical Center, School of Medicine, University of California, Los Angeles, Bldg. N25, 1000 W. Carson St., 90509 Torrance, CA;(2) Sepracor, Inc, 01752 Marlborough, MA |
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| Abstract: | Conclusions MCs promote chronic inflammation and the development of airway remodeling in asthma through MC-derived cytokines, chemokines,
proteases, and interaction with other immune cells (T cells and eosinophils). The rapid innovation of genetic technologies
and new techniques of MC knock-out/knock-in animal model are improving our understanding of the complex relationships between
the various cell types involved in the immune network of the airway and will clarify the role of MCs in the pathogenesis of
asthma. Targeting MCs may be a new treatment modality in treatment and prevention of asthma. |
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