| 茶多酚对缺血心肌组织PIP2和IP3水平的影响 |
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| 引用本文： | 柯永胜,赵振东.茶多酚对缺血心肌组织PIP2和IP3水平的影响[J].中国临床药理学与治疗学,1996,1(1):21-22. |
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| 作者姓名： | 柯永胜 赵振东 |
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| 作者单位： | 皖南医学院弋矶山医院，皖南医学院弋矶山医院 芜湖 241001，芜湖 241001 |
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| 摘 要： | 目的 观察茶多酚对急性缺血心肌磷酯肌醇代谢的影响。方法 结扎大鼠左冠状动脉前降支造成急性心肌缺血模型。结果 急性心肌缺血10min,心肌磷酯肌醇代谢功能增强,缺血组心肌PIP_2、IP_3水平明显高于非缺血对照组(P<0.01);茶多酚能显著抑制急性心肌缺血所致心肌组织PIP_2和IP_3水平的升高。结论 茶多酚心肌保护作用与抑制缺血心肌组织磷酯肌醇代谢有关。
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| 关 键 词： | 心肌缺血 磷酯酰肌醇-4 5-二磷酸 肌醇-1 4 5-三磷酸 茶多酚 |
Effects of tea ployphenols on levels of PIP_2,TP_3 of acute schemic myocardium in rat |
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| Ke Yongsheng Zhao Zhengdong.Effects of tea ployphenols on levels of PIP_2,TP_3 of acute schemic myocardium in rat[J].Chinese Journal of Clinical Pharmacology and Therapeutics,1996,1(1):21-22. |
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| Authors: | Ke Yongsheng Zhao Zhengdong |
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| Abstract: | Aim The effects of tea polyphenols ( TP) on phosphoinositides metablism in rats with acute ischemic myocardium were studied.Methods The model of acut myocardial ischemia in rats was prepared by ligating anterior decending branch of left coronary artery . Results The function of the phosphoinositide signal system was enhanced 10 min after acute myocardial ischemia. Both of the levels of phosphotidylinositol - 4,5 - biphosphate(PIP2 ) and inositol - 1, 4, 5 - triphosphate (IP3)were higher than those in the non - ischemic control group(P< 0. 01). The rise of the levels of PIP2 and IPa caused by myocardial ischemia were remarkedly inhibited by the TP and a dose - effect relationship was observed ( P< 0. 01) .Conclusion The results showed that the protection of TP was relation to its inhibiting the function of phosphoinositides metablism in acute ischemic myocardium. |
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| Keywords: | Myocardial ischemia Phosphotidylinositol - 4 5 - biphosphate Inositol - 1 4 5 - triphosphate Tea polyphenols |
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