| 壳聚糖/纳米羟基磷灰石分层复合支架的生物相容性研究 |
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| 引用本文： | 祁军,陈安民,郭风劲,孙淑珍,谢柏臻,张伟凯,张树威. 壳聚糖/纳米羟基磷灰石分层复合支架的生物相容性研究[J]. 北京生物医学工程, 2008, 27(1): 53-56 |
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| 作者姓名： | 祁军 陈安民 郭风劲 孙淑珍 谢柏臻 张伟凯 张树威 |
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| 作者单位： | 华中科技大学附属同济医院骨科,武汉,430030;武汉理工大学材料学院,武汉,430070 |
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| 摘 要： | 制备壳聚糖/纳米羟基磷灰石(CS/nHA)分层复合支架,对其进行细胞毒性评价.分离培养大鼠软骨细胞接种于支架,相差显微镜和扫描电镜观察细胞的黏附及生长情况.动物皮下埋植试验观察其组织相容性.实验结果证实壳聚糖/纳米羟基磷灰石分层复合支架具有良好的生物相容性,有望成为较好的骨软骨组织工程支架.
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| 关 键 词： | 壳聚糖 纳米羟基磷灰石 生物相容性 组织工程 |
| 文章编号： | 1002-3208(2008)01-0053-04 |
| 修稿时间： | 2007-07-16 |
Biocompatibility of chitosan/nano-hydroxyapatite composite scaffold materials |
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| QI Jun,CHEN Anmin,GUO Fengjin,SUN Shuzhen,XIE Bozhen,ZHANG Weikai,ZHANG Shuwei. Biocompatibility of chitosan/nano-hydroxyapatite composite scaffold materials[J]. Beijing Biomedical Engineering, 2008, 27(1): 53-56 |
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| Authors: | QI Jun CHEN Anmin GUO Fengjin SUN Shuzhen XIE Bozhen ZHANG Weikai ZHANG Shuwei |
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| Affiliation: | QI Jun1,CHEN Anmin1,GUO Fengjin1,SUN Shuzhen2,XIE Bozhen1,ZHANG Weikai1,ZHANG Shuwei1 1 Department of Orthopedics,Tongji Hospital of Huazhong University of Science , Technology,Wuhan 430030,2 Department of Material Science,Wuhan University of Technology,Wuhan 430070 |
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| Abstract: | The cytotoxicity of chitosan/nano-hydroxyapatite(CS/nHA)composite scaffold material was evaluated through the determination of the chondrocytes cells relative proliferation.The chondrocytes of rats were isolated and multiplied in vitro,and then the chondrocytes were seeded onto the scaffold.The effect of the CS/nHA composite scaffold on the cell adhesion,proliferation,morphological changes were observed by the phase-contrast microscopy and scanning electron microscopy(SEM).The in vivo tissue response to CS/... |
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| Keywords: | chitosan nano-hydroxyapatite biocompatibility tissue engineering |
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