妊高征患者和正常孕妇妊娠晚期血小板参数的变化

目的　探讨妊高征 (PIH )患者和正常孕妇妊娠晚期血小板参数变化及临床应用价值。方法　采用CD 370 0SL全自动血液分析仪分别对 5 0例妊高征患者 (妊高征组 )、15 0例正常孕妇以及 15 0例正常非孕妇女 (对照组 )血液标本进行血小板计数、平均血小板体积 (MPV)、血小板分布宽度 (PDW )以及红细胞压积 (Hct)检测。结果　妊高征组的MPV、PDW明显高于正常孕妇组 (P <0 0 5 ) ,而此二组又明显高于对照组 (P <0 0 1) ;妊高征组的PLT明显低于对照组 (P>0 0 1)。三组间的Hct无显著性差异 (P >0 0 5 )。结论　妊高征患者妊娠晚期由于血小板消耗和破坏增加 ,导致血小板减少 ,MPV、PDW明显增加。检测血小板参数能为临床预测妊高征的发生提供一定的参考。

The changes of platelet indices during late gestation in normal pregnant women and patients with pregnancy induced hypertension

Objective To study the changes of platelet indices and its clinical practice during late gestation in normal pregnant women and patients with pregnancy induced hypertension(PIH). Methods Platelet count,mean platelet volume(MPV),platelet volume distribution width(PDW) and hematocrit(Hct) were measured by CD-3700 SL hematology analyzer in 50 patients with PIH,150 normal pregnant women and 150 normal non-pregnant women. Results Both MPV and PDW in patients with PIH and in normal pregnant women were significantly higher than those in the control group(P<0.01). MPV and PDW in patients with PIH were significantly higher than those in the normal pregnant women(P<0.05). Platelet count in patients with PIH was significantly lower than that in the control group(P<0.01). No difference was found in hematocrit between these groups(P>0.05). Conclusion The decrease of platelet and increase of MPV and PDW are caused by a progressive platelet consumption and destruction during PIH. The examination of platelet indices may offer a reference to predict PIH.