High frequency of Panton-Valentine leukocidin genes in invasive methicillin-susceptible <Emphasis Type="Italic">Staphylococcus aureus</Emphasis> strains and the relationship with methicillin-resistant <Emphasis Type="Italic">Staphylococcus aureus</Emphasis> in Córdoba,Argentina |
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Authors: | C Sola H A Saka A Vindel J L Bocco Córdoba S aureus Collaborative Study Group |
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Institution: | (1) Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI—CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y M. Allende s/n Ciudad Universitaria, 5000 Córdoba, Argentina;(2) Laboratorio de Enfermedades Infecciosas Nosocomiales, Instituto de Salud Carlos III, Centro Nacional de Microbiología, 28220 Majadahonda, Madrid, Spain |
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Abstract: | In the study presented here, the genetic characteristics of methicillin-susceptible Staphylococcus aureus (MSSA) strains isolated from patients attending hospitals in the city of Córdoba, Argentina, during 1999–2002 were evaluated
to determine their genetic relationship with methicillin-resistant S. aureus (MRSA) clones as part of an effort to control the potential emergence of new epidemic MRSA strains. The results showed there
is a high frequency of MSSA strains carrying Panton-Valentine leukocidin genes in invasive infections in Córdoba, Argentina,
particularly in those occurring in hospital settings. Panton-Valentine leukocidin genes were found in the genomic background
of one clone (ST30-N pulsotype) belonging to a successful internationally distributed MSSA lineage (clonal complex 30), which
is closely related to the EMRSA-16 pandemic clone. These genes were also detected in the ancestral clone (ST5-M pulsotype)
of the most prevalent MRSA epidemic clone causing healthcare-associated infections in this region, known as the Cordobes/Chilean
clone. The molecular characterization of circulating MSSA strains, including the detection of Panton-Valentine leukocidin
genes, is thus a useful marker for investigating the evolving epidemiology of hospital- and community-acquired MRSA clones. |
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