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Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC) |
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| Authors: | Fatemeh Saberi Hosnijeh Isabelle Romieu Valentina Gallo Elio Riboli Anne Tjønneland Jytte Halkjær Guy Fagherazzi Françoise Clavel-Chapelon Laure Dossus Annie Lukanova Rudolf Kaaks Antonia Trichopoulou Pagona Lagiou Michael Katsoulis Salvatore Panico Giovanna Tagliabue Catalina Bonet Miren Dorronsoro José María Huerta Eva Ardanaz Maria-José Sánchez Dorthe Johansen Signe Borgquist Petra Peeters H. Bas Bueno-de-Mesquita Martine M. Ros Ruth C. Travis Timothy J. Key Paolo Vineis Roel Vermeulen |
| Affiliation: | 1. Division Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Jenalaan 18D, PO Box 80178, 3508 TD, Utrecht, Netherlands 2. Zanjan University of Medical Science, Zanjan, Iran 3. International Agency for Research on Cancer (IARC-WHO), Lyon, France 4. Division of Epidemiology, Public Health and Primary Care, Faculty of Medicine, Imperial College, London, UK 5. Danish Cancer Society Research Center, Copenhagen, Denmark 6. Inserm, U1018, Gustave Roussy Institute, Villejuif, France 7. Paris South University, UMRS 1018, Villejuif, France 8. Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany 10. Hellenic Health Foundation, Athens, Greece 9. Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece 11. Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece 12. Department of Clinical and Experimental Medicine Federico II University, Naples, Italy 13. Environmental Epidemiology and Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy 14. Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), Barcelona, Spain 15. Public Health Division of Gipuzkoa, Basque Regional Health Department and Biodonostia/Ciberesp, San Sebastián, Spain 16. Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain 17. CIBER Epidemiología y Salud Pública (CIBERESP), Pamplona, Spain 18. Navarre Public Health Institute, Pamplona, Spain 19. Andalusian School of Public Health, Granada, Spain 20. Department of Surgery, Malm? University Hospital, Lund University, Malm?, Sweden 21. Clinical Sciences, Department of Oncology, Lund University, Lund, Sweden 22. Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands 23. National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands 24. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands 25. Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands 26. Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK |
| Abstract: | PurposeOverweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC).MethodsDuring follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia.ResultsNo associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height.ConclusionThe study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed. |
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