血清妊娠血浆相关蛋白A与冠心病斑块稳定性的关系

目的研究血清妊娠血浆相关蛋白A(PAPP-A)水平与冠心病斑块稳定程度的相关性。方法用酶联免疫吸附法(ELISA)检测了230例拟诊冠心病患者的PAPP-A水平,其中急性心肌梗死50例,不稳定型心绞痛110例,稳定型心绞痛40例,另30例为非冠心病,并对冠心病患者进行冠状动脉造影病变形态学分析,比较不同类型的冠心病及不同形态斑块的PAPP-A水平。结果血清PAPP-A在急性心肌梗死组为(26.13±4.65)mIU/L,不稳定型心绞痛组为(20.37±5.78)mIU/L,明显高于稳定型心绞痛组(12.82±3.94)mIU/L和非冠心病组(10.70±2.86)mIU/L(均P<0.01,不稳定型心绞痛组和急性心肌梗死组比较,P<0.05)。血清PAPP-A在Ⅱ型斑块组中的水平为(24.52±4.82)mIU/L,明显高于其他型斑块组(16.82±5.37)mIU/L及非冠心病组(10.70±2.86)mIU/L(均P<0.01)。结论血清PAPP-A水平与冠心病斑块稳定性相关。

Relationship between Serum Pregnancy-Associated Plasma Protein-A and Plaque Stability of Coronary Lesion

Objective To study the relationship between serum pregnancy-associated plasma protein-A(PAPP-A)and plaque stability of coronary lesion.Methods Levels of serum PAPP-A were measured among 230 patients seemed as coronary heart disease(CHD)including 50 cases with acute myocardial infraction(AMI),110 cases with unstable angina pectoris(UAP),40 cases with stable angina pectoris(SAP)and 30 cases without CHD as control by enzyme-linked immunoassay(ELISA).Anginographic morphology of the coronary lesion was assessed in patients with CHD.Then,the serum PAPP-A levels were compared among different types of CHD and plaque.Results Serum PAPP-A levels were significantly higher in the AMI group(26.13±4.65)mIU/L and UAP group(20.37±5.78)mIU/L than in the SAP group(12.82±3.94)mIU/L and without CHD group(10.70±2.86)mIU/L(P<0.01,UAP group vs AMI group,P<0.05).Serum PAPP-A levels were significantly higher in the type Ⅱ lesions(24.52±4.82)mIU/L than in the other type lesions group(16.82±5.37)mIU/L and in the control group(10.70±2.86)mIU/L(P<0.01).Conclusion Serum PAPP-A level was closely associated with plaque stability of coronary lesion.