糖耐量减低与脑梗死患者颈动脉粥样硬化的关系初探

选择2006年7月至2008年1月在我院神经内科住院的初发脑梗死且排除糖尿病患者160例，根据简化糖耐量（OGTT）实验结果分为糖耐量减低（IGT）组80例和耐量正常（NGT）组80例，采用动脉血管超声检查颈动脉粥样硬化及颈动脉狭窄程度。结果示脑梗死IGT组和NGT组颈动脉粥样硬化斑块发生率分别为87．5％（70／80）、63．8％（51／80），差异有统计学意义（X^2=12．240，P〈0．001）；颈动脉狭窄发生率分别为63．8％（51／80）、47．5％（38／80），差异有统计学意义（X^2=4．279，P=0．039）；脑梗死IGT组颈动脉狭窄程度较脑梗死NGT组增加（X^2=21．95，P〈0．01）。提示IGT可能与脑梗死患者颈动脉粥样硬化和颈动脉狭窄有关。

Association of impaired glucose tolerance with carotid atherosclerosis in patients with cerebral ischemia

One hundred and sixty non-diabetic patients with cerebral ischemia of primary onset were enrolled in the study. The patients were divided into impaired glucose tolerance (IGT) group and normal glucose tolerance (NGT) group according to the oral glucose tolerance test (OGTT). Carotid atherosclerosis and carotid artery stenosis were examined with vascular Doppler ultrasonic detection. The incidence rates of carotid atherosclerosis in IGT group and NGT group were 87. 5% (70/80)and 63.8% (51/80)respectively (χ2= 12.240,P <0.001);the incidence rates of carotid stenosis in IGT group and NGT group were 63.8% (51/80) and 47. 5 % (38/80), respectively(χ2 =4. 279, P =0. 039);the degree of carotid artery stenosis in IGT group was higher than that in NGT group(χ2= 21.95, P < 0. 01). The results indicate that IGT may be related to atherosclerosis and stenosis of carotid artery in cerebral ischemic patients.