The SLICC inception cohort for atherosclerosis |
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Authors: | Murray B Urowitz Dafna D Gladman |
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Institution: | (1) University of Toronto Lupus Clinic, Toronto, Canada;(2) Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Room 1E-409, 399 Bathurst Street, Toronto, ON, Canada, M5T 2S8 |
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Abstract: | The Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) is a group of rheumatologists and methodologists
from 27 international centers who have a particular interest and expertise in systemic lupus erythematosus. Initially, its
efforts focused on development and validation of disease activity and damage indices. In 2000, the SLICC Registry for Atherosclerosis
was established to determine the incidence, prevalence, nature, and risk factors of atherosclerotic coronary artery disease
in systemic lupus erythematosus. Risk factors for coronary artery disease at presentation to the cohort were reported, as
well as their accumulation over the first few years. Development of the metabolic syndrome was also described. Among the first
1078 patients who entered the cohort, 61 vascular events have occurred in 47 patients who were older at diagnosis and more
likely male and hypertensive than were the patients without vascular events. Additional studies using this cohort are ongoing. |
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Keywords: | |
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