| 厄贝沙坦对糖尿病大鼠心肌组织血管紧张素转换酶2表达的影响 |
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| 引用本文： | 胡园园,沈洁,朱艳,唐杰龙,刘帅.厄贝沙坦对糖尿病大鼠心肌组织血管紧张素转换酶2表达的影响[J].南方医科大学学报,2010,30(6). |
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| 作者姓名： | 胡园园 沈洁 朱艳 唐杰龙 刘帅 |
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| 作者单位： | 1. 南方医科大学南方医院内分泌代谢科,广东,广州,510515
2. 佛山南海人民医院内分泌科,广东,佛山,528200 |
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| 摘 要： | 目的 探讨厄贝沙坦对糖尿病大鼠心肌组织血管紧张素转换酶2(ACE2)mRNA表达的影响.方法 将30只8周龄雄性Wismr大鼠随机分为正常对照组(Ctrl组,n=7)、糖尿病组(DM组,n=14)和50mg/kg厄贝沙坦干预组(DM+Irb50组,n=9),一次性腹腔注射链脲佐菌素5 mg/kg,72 h后血糖大于16.7 mmol/L纳入糖尿病组,造模成功后4周,灌胃法给予相应剂量厄贝沙坦,继续喂养8周.ELISA测定各组大鼠心肌组织血管紧张素Ⅱ(AngⅡ)含量;实时荧光定量PCR检测各组大鼠心肌组织ACE2 mRNA表达.结果 糖尿病大鼠心肌组织AngⅡ显著升高,厄贝沙坦干预后,AngⅡ水平显著降低(P<0.001).DM+Irb50组大鼠心肌组织ACE2 mRNA表达显著高于正常对照组和DM组(P<0.05).结论 厄贝沙坦可上调心肌组织ACE2 mRNA表达,这可能是其改善心功能的机制之一.
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| 关 键 词： | 糖尿病 心肌组织 血管紧张素转换酶2 厄贝沙坦 血管紧张素Ⅱ |
Effect of irbesartan on ACE2 expression in diabetic rat myocardium |
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| HU Yuan-yuan,SHEN Jie,ZHU Yan,TANG Jie-long,LIU Shuai.Effect of irbesartan on ACE2 expression in diabetic rat myocardium[J].Journal of Southern Medical University,2010,30(6). |
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| Authors: | HU Yuan-yuan SHEN Jie ZHU Yan TANG Jie-long LIU Shuai |
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| Institution: | HU Yuan-yuan1,SHEN Jie1,ZHU Yan1,TANG Jie-long1,LIU Shuai2 1Department of Endocrinology and Metabolism,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China,2Department of Endocrinology and Metabolism,Nanhai People's Hospital,Foshan 528200 |
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| Abstract: | Objective To explore the effect of irbesartan on angiotensin-converting enzyme 2(ACE2) mRNA expression in diabetic rat myocardium.Methods Thirty 8-week-old male Wistar rats were randomly divided into control group(n=7),diabetic model group(n=14) and irbesartan group(n=9).Diabetes was induced by a single intraperitoneal injection of STZ(55 mg/kg),a blood glucose >16.7 mmol/L 72 h after the injection indicated successful establishment of diabetes.Four weeks after the modeling,the rats in irbesartan group were... |
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| Keywords: | diabetes myocardium angiotensin-converting enzyme 2 irbesartan angiotensin II |
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