| 垂体肿瘤转化基因在人肾透明细胞癌中的表达及意义 |
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| 引用本文： | 汤华明,谈健,崔飞伦.垂体肿瘤转化基因在人肾透明细胞癌中的表达及意义[J].南方医科大学学报,2010,30(7):1712. |
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| 作者姓名： | 汤华明 谈健 崔飞伦 |
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| 作者单位： | 江苏省镇江市第一人民医院泌尿外科,江苏,镇江,212002 |
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| 摘 要： | 目的 探讨垂体肿瘤转化基因(PTTG)在人肾透明细胞癌中的表达及其意义.方法 采用免疫组织化学法分别检测正常肾脏组织及肾透明细胞癌组织中PTTG蛋白的表达.结果 在正常肾脏和肾透明细胞癌组织中PTTG蛋白的表达存在显著差异(P<0.001),肾透明细胞癌中PTTG蛋白表达率(74.56%)明显高于正常肾组织(11.11%).在肾透明细胞癌组织中,PTTG蛋白表达阳性率与肾透明细胞癌的肿瘤大小、临床分期和Fuhrman分级呈正相关,差异具有显著性(P=0.009、0.008和0.035).结论 PTTG在肾透明细胞癌组织中高表达,与肾透明细胞癌的发生、发展密切相关.
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| 关 键 词： | 肾透明细胞癌 垂体肿瘤转化基因 免疫组织化学 |
Expression of pituitary tumor transforming gene in human renal clear cell carcinoma and its significance |
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| TANG Ming-hua,TAN Jian,CUI Fei-lun.Expression of pituitary tumor transforming gene in human renal clear cell carcinoma and its significance[J].Journal of Southern Medical University,2010,30(7):1712. |
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| Authors: | TANG Ming-hua TAN Jian CUI Fei-lun |
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| Institution: | TANG Ming-hua,TAN Jian,CUI Fei-lun Department of Urology,Zhenjiang First People's Hospital,Zhenjiang 212002,China |
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| Abstract: | Objective To explore the expression of pituitary tumor transforming gene (PTTG) in human renal clear cell carcinoma (RCCC) and its significance. Methods PTTG protein expression was detected by immunohistochemistry in 87 RCCC and 45 paired normal renal tissues. Results PTTG was expressed differentially between the normal renal and RCCC tissues. Compared with normal tissues, the primary RCCC tissues showed significantly increased expression of PTTG protein (P<0.001). The positive rate of PTTG protein was posi... |
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| Keywords: | renal clear cell carcinoma pituitary tumor transforming gene immunohistochemistry |
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