| 六味地黄丸对自发性糖尿病大鼠胰腺的保护作用 |
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| 引用本文： | 李佳,薛耀明,钱毅,朱波,潘永华,张燕.六味地黄丸对自发性糖尿病大鼠胰腺的保护作用[J].南方医科大学学报,2010,30(6). |
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| 作者姓名： | 李佳 薛耀明 钱毅 朱波 潘永华 张燕 |
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| 作者单位： | 南方医科大学南方医院内分泌代谢科,广东,广州,510515 |
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| 基金项目： | 国家自然科学基金，广东省科技计划项目(社会发展攻关)，广东省科技计划项目 |
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| 摘 要： | 目的 通过观察六味地黄丸对自发性2型糖尿病OLETF大鼠胰腺形态学的影响,探讨六味地黄丸预防糖尿病的可能机制.方法 自发性2犁糖尿病大鼠OLETF鼠40只,随机分为六味地黄丸干预组和对照组,LETO鼠10只作为正常对照组.干预组从8周龄起以六味地黄丸2.4 mg·kg-1·d-1灌胃给药,其余两组以等量清水灌胃.定期OGTT试验.于8、32和40周龄时分批宰杀大鼠.分离胰腺.HE染色观察胰岛结构;Masson 三色染色观察胰岛纤维化程度.结果 随着周龄的延长,对照组大鼠胰岛逐渐出现纤维化,萎缩;干预组的胰岛结构保存明显好于对照组.通过Masson染色,可见干预组胰岛纤维化程度明显轻于同周龄对照组.LETO组大鼠胰腺结构随着周龄延长无明显变化.十预组从30周龄开始出现糖尿病.至40周糖尿病发病率28.6%,显著低于对照组(P<0.01).结论 六味地黄丸早期干预能明显保护OLETF大鼠胰岛结构减少其纤维化,可能是其预防糖尿病的机制之一.
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| 关 键 词： | 2型糖尿病 六味地黄丸 OLETF鼠 胰腺 组织学 |
Effects of Liuweidihuang pills on pancreatic islet structure in OLETF rats |
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| LI Jia,XUE Yan-ming,QIAN Yi,ZHU Bo,PAN Yong-hua,ZHANG Yan.Effects of Liuweidihuang pills on pancreatic islet structure in OLETF rats[J].Journal of Southern Medical University,2010,30(6). |
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| Authors: | LI Jia XUE Yan-ming QIAN Yi ZHU Bo PAN Yong-hua ZHANG Yan |
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| Institution: | LI Jia,XUE Yao-ming,QIAN Yi,ZHU Bo,PAN Yong-hua,ZHANG Yan Department of Endocrinology and Metabolism,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China |
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| Abstract: | Objective To study the effects of Liuweidihuang pills on pancreatic islet structure in OLETF(Otsuka Long-Evans Tokushima Fatty) rats.Methods Forty male OLETF rats were divided randomly into Liuweidihuang pills group(Liuwei group) and control group(n=20).Ten male LETO rats were used as normal control group(LETO group).The rats in Liuwei group were given Liuweidihuang pills at the daily dose of 2.4 mg/kg intragastrically since the age of 8 weeks.Blood glucose was determined by OGTT.The rats were sacrificed at... |
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| Keywords: | type 2 diabetes Liuweidihuang pills OLETF rats pancreas |
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