| TrxR2基因多态性与大骨节病易感性关系的初步研究 |
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| 引用本文： | Lu W,Mo XY,Xiong YM. TrxR2基因多态性与大骨节病易感性关系的初步研究[J]. 南方医科大学学报, 2010, 30(10): 2246-2248 |
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| 作者姓名： | Lu W Mo XY Xiong YM |
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| 作者单位： | 1. 西安交通大学生命科学与技术学院,陕西,西安,710049
2. 西安交通大学医学院环境与疾病相关基因教育部重点实验室,陕西,西安,710061 |
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| 基金项目： | 国家自然科学基金,陕西省自然科学基金 |
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| 摘 要： | 目的 研究硫氧还蛋白还原酶2(TrxR2)基因单核苷酸多态性位点与大骨节病(KBD)易感性的关系.方法 采用聚合酶链式反应-限制性片段长度多态性(PCR-EFLP)技术检测84例KBD患者和109例正常对照者TrxR2基因rs5748469位点的基因型.结果 KBD组A/A,A/C,C/C基因型频率分别为83.33%,15.48%～1.19%,正常对照组A/A和A/C基因型分别为74.31%和25.69%,二组之间无显著性差异(P=0.13>0.05).结论 该位点与大骨节病易感性之间不具有明显的相关性.
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| 关 键 词： | 硫氧还蛋白还原酶-2 单核苷酸多态性 大骨节病 聚合酶链式反应-限制性片段长度多态性 |
TrxR2 gene polymorphisms may not be associated with the susceptibility to Kashin-Beck disease |
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| Lu Wei,Mo Xiao-yan,Xiong Yong-min. TrxR2 gene polymorphisms may not be associated with the susceptibility to Kashin-Beck disease[J]. Journal of Southern Medical University, 2010, 30(10): 2246-2248 |
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| Authors: | Lu Wei Mo Xiao-yan Xiong Yong-min |
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| Affiliation: | LU Wei1,MO Xiao-yan1,XIONG Yong-min2 1School of Life Science and Technology,Xi'an Jiaotong University,Xi'an 710049,China,2Key Laboratory of Environment and Gene Related to Diseases,Xi'an Jiaotong University College of Medicine,Xi'an 710061 |
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| Abstract: | Objective To study the association between single nucleotide polymorphisms of thioredoxin reductase-2(TrxR2) gene and the susceptibility to Kashin-Beck disease(KBD).Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was used to analyze the genotype frequencies of rs5748469 in TrxR2 gene in 84 KBD patients and 109 healthy control subjects.Results The genotype frequencies of A/A,A/C,and C/C in the KBD patients were 83.33%,15.48% and 1.19%,as compared with the frequencies of 7... |
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| Keywords: | thioredoxin reductase-2 single nucleotide polymorphism Kaschin-Beck disease polymerase chain reaction-restriction fragment length polymorphism |
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