阿奇霉素连续和间歇给药治疗支原体肺炎的疗效及耐药性分析

目的 研究连续与间歇注射阿奇霉素治疗支原体大鼠肺炎模型的疗效与耐药性差别.方法 采用滴鼻法建立大鼠支原体肺炎感染模型,模型随机分为连续组和间歇组.连续组连续腹腔注射6d,间歇组采用间歇腹腔注射方式注射3d,停3 d,重复2次,分别于给药前,给药后3、6、9、12 d进行肺灌洗分离支原体,进行体外药敏实验,测定MIC值.并对大鼠肺部进行病理检查.结果 间歇给药组疗效优于连续给药组,治疗12d时连续给药组MIC值高于间歇给药组.结论 阿奇霉素间歇给药方式治疗支原体感染肺炎优于连续给药方式,且与连续给药方式相比较不易引起耐药性.

Continuous versus intermittent azithromycin administration for treatment of Mycoplasma pneumonia-induced pneumonia: effects and drug resistance in rats

Objective To evaluate the efficacy and drug resistance of azithromycin administered via continuous infusion versus intermittent administration in rats with Mycoplasma pneumonia-induced pneumonia. Methods Pneumonia was induced in rats by intranasal administration of mycoplasma suspension. The rats with established pneumonia were randomly divided into continuous and intermittent infusion groups with intraperitoneal azithromycin injection on a daily basis for 6 consecutive days, or for 3 consecutive days follo...