| 雷奈酸锶对模拟失重雄性大鼠骨质疏松的防治作用 |
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| 引用本文： | 杨锐,黄震,蔡德鸿,张桦,赖阿娜,张振,孙平,陈宏.雷奈酸锶对模拟失重雄性大鼠骨质疏松的防治作用[J].南方医科大学学报,2010,30(4):834. |
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| 作者姓名： | 杨锐 黄震 蔡德鸿 张桦 赖阿娜 张振 孙平 陈宏 |
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| 作者单位： | 1. 南方医科大学珠江医院内分泌科,广东,广州,510282
2. 南方医科大学珠江医院外科学教研室,广东,广州,510282 |
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| 摘 要： | 目的 观察雷奈酸锶对模拟失重雄性大鼠质疏松的影响.方法 雄性SD大鼠27只,随机平均分为3组:A组为对照组,B组为尾吊模拟失重组,C组为悬吊模拟失重同时给以雷奈酸锶灌胃组.A和B组灌等量生理盐水,各组实验期均为28d.测骨代谢指标,右侧股骨的骨密度和骨矿盐含量,扫描电镜观察股骨颈超微结构.结果 B组大鼠血清碱性磷酸酶、骨密度、骨矿盐含量水平显著低于A组相应的指标(P<0.05),血钙、血磷无显著差异(P>0.05),组骨小梁表面胶原纤维排列杂乱,松散,可见骨吸收现象;C组大鼠上述生化及代谢指标显著性高于B组大鼠(P<0.05),C组大鼠骨小梁较B组数量增多,厚度增加,骨吸收减少.结论 雷奈酸锶能明显降低模拟失重大鼠股骨颈的骨丢失,增加骨形成,防治骨质疏松症.
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| 关 键 词： | 雷奈酸锶 模拟失重 骨质疏松 骨密度 生化指标 扫描电镜 |
Preventive and therapeutie effect of strontium ranelate on osteoporosis in rats subjected to simulated weightlessness |
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| YANG Rui,HUANG Zhen,CAI De-hong,ZHANG Hua,LAI A-na,ZHANG Zhen,SUN Ping,CHEN Hong.Preventive and therapeutie effect of strontium ranelate on osteoporosis in rats subjected to simulated weightlessness[J].Journal of Southern Medical University,2010,30(4):834. |
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| Authors: | YANG Rui HUANG Zhen CAI De-hong ZHANG Hua LAI A-na ZHANG Zhen SUN Ping CHEN Hong |
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| Institution: | YANG Rui1,HUANG Zhen2,CAI De-hong1,ZHANG Hua1,LAI A-na1,ZHANG Zhen1,SUN Ping1,CHEN Hong1 1Department of Endocrinology,2Surgery Teaching and Research Section,Zhujiang Hospital,Southern Medical University,Guangzhou 510282 |
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| Abstract: | Objective To study the effects of strontium ranelate on osteoporosis induced by simulated weightlessness in male rats.Methods Twenty-seven male SD rats were randomly divided into 3 groups,namely the normal control group (group A) and two groups of weightlessness simulated by tail suspension (groups B and C).The rats in group C were treated with strontium ranelate,and those in the other two groups were given the same dose of normal saline for 28 consecutive days.Results The rats in group B showed significant... |
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| Keywords: | strontium ranelate weightlessness osteoporosis bone mineral density biochemical indices scanning electron microscope |
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