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| 阿尔茨海默病模型大鼠PDI及P53的表达及丁苯酞对其的影响 | |
| 引用本文： | 侯德仁,薛俐,唐交春,周军,孙娟娟.阿尔茨海默病模型大鼠PDI及P53的表达及丁苯酞对其的影响[J].南方医科大学学报,2010,30(9):2104. |
| 作者姓名： | 侯德仁 薛俐 唐交春 周军 孙娟娟 |
| 作者单位： | 1. 中南大学湘雅三医院,神经内科,湖南长沙,410013 2. 中南大学湘雅三医院,中医科,湖南长沙,410013 3. 中南大学湘雅三医院,医学实验中心,湖南长沙,410013 |
| 基金项目： | 湖南省自然科学基金，湖南省科技计划项目 |
| 摘 要： | 目的 研究阿尔茨海默病模型大鼠PDI、P53的表达及丁苯酞对其影响.方法 成年雄性SD大鼠60只,随机分为模型组、丁苯酞组及对照组,每组20只;通过向大鼠海马内注射Aβ1-42建立阿尔茨海默病模型,喂养60d后用Y型迷宫检测大鼠学习记忆能力、免疫组织化学染色检测大鼠脑组织PDI和P53的表达.结果 与对照组比较,模型组大鼠学习记忆能力下降,其海马CA1区PDI阳性细胞减少,皮层P53表达增加,差异均有统计学意义(P＜0.01);与模型组比较,丁苯酞组大鼠海马CA1区PDI阳性细胞数明显增加,皮层P53表达减少,差异有统计学意义(P＜0.01).结论 丁苯酞改善阿尔茨海默病大鼠学习记忆能力可能与其增加PDI、抑制P53的表达有关. |
| 关 键 词： | 阿尔茨海默病 丁苯酞 |
Butylphthalide improves learning and memory abilities of rats with Alzheimer's disease possibly by enhancing protein disulfide isomerase and inhibiting P53 expressions |
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| HOU De-ren,XUE Li,TANG Jiao-chun,ZHOU Jun,SUN Juan-juan.Butylphthalide improves learning and memory abilities of rats with Alzheimer's disease possibly by enhancing protein disulfide isomerase and inhibiting P53 expressions[J].Journal of Southern Medical University,2010,30(9):2104. | |
| Authors: | HOU De-ren XUE Li TANG Jiao-chun ZHOU Jun SUN Juan-juan |
| Institution: | HOU De-ren1,XUE Li2,TANG Jiao-chun1,ZHOU Jun3,SUN Juan-juan1 1Department of Neurology,2Department of Traditional Chinese Medicine,3Center of Medical Experiment,Third Xiangya Hospital,Central South University,Changsha 410013,China |
| Abstract: | Objective To determine the effect of butylphthalide on the expressions of protein disulfide isomerase(PDI) and P53 in the brain tissue of rats with Alzheimer's disease(AD).Methods Sixty male adult rats were randomly divided into AD model group,butylphthalide group and control group(n=20).AD models were established by injecting beta-amyloid protein 1-42 into the hippocampus of rats.Sixty days later,the learning and memory abilities of the rats were evaluated using Y-maze test,and the expressions of PDI and P... |
| Keywords: | PDI P53 |
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