E838对CTX化疗损伤小鼠的保护作用

 目的 观察E838对环磷酰胺所致小鼠损伤的保护作用。 方法 对小鼠采用连续5天腹腔注射E838药物，从第3天同时给予环磷酰胺（CTX），阳性对照为茜草双酯，观察外周血白细胞、骨髓有核细胞数、内源性脾结节形成（CFU-S）、脾脏指数及胸腺指数的变化。 结果 E838可明显减轻化疗所致小鼠免疫功能的抑制，并可使化疗后小鼠的体重恢复增长, 白细胞、骨髓有核细胞和CFU-S明显高于对照组，差异有统计学意义（P<0.05）。中、高剂量组白细胞与茜草双酯组比较，差异有统计学意义（P<0.05）。 结论 提示E838具有对抗化疗损伤的作用。

Protection of E838 on CTX-induced Mice's Injury

Objective To observe the protection of E838 on cyclophosphamide -induced mice’s injury. Methods The E838 were injected into mice intra peritoneally for 5 days, and the positive control group was madder diester. CTX was injected on the third day. We observed the changes in peripheral blood leukocytes, bone marrow nucleated cells, endogenous spleen nodule formation (CFU-S), spleen and thymus index. Results E838 can significantly reduce the chemotherapy induced immune function inhibition in mice,and accelerate the weight grow after chemotherapy.Numbers of peripheral blood leukocytes bone, marrow nucleated cells and CFU-S significantly increased compared with the control group and there was significant statistically difference (P<0.05). There was significant statistically difference (P<0.05)in the numbers of blood leukocytes of middle and high dose group compared with madder diacrylate. Conclusion E838 can antagonize the chemotherapy injury.