Radioisotope therapy of cystic craniopharyngeomas |
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Authors: | Ludwig Strauss Volker Sturm Peter Georgi Wolfgang Schlegel Hermann Ostertag John H Clorius Gerhard van Kaick |
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Institution: | German Cancer Research Center and the University of Heidelberg, Heidelberg, Germany |
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Abstract: | Eighteen patients suffering from cystic craniopharyngeoma were treated with intracavitary irradiation. The beta-emitting radioisotope 90y (2.25 MeV) was instilled into the cyst following stereotactic puncture of the space-occupying lesion. The surgical approach was planned using angiograms and reconstructed transmission computer tomography (TCT) coronal and saggital sections. Therapy was devised to deliver 20,000 rad to the cyst's wall. Eleven patients received follow-up TCT examinations after four months. Eight of 11 patients had a significant volume decrease in the craniopharyngeoma cyst. In two patients, the cystic volume remained unchanged; one had progression of disease. It is concluded that the intracavitary treatment of cystic craniopharyngeoma will result in a reduction of the size of the space-occupying lesion. |
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Keywords: | Reprint requests to: Ludwig Strauss M D Institute of Nuclear Medicine German Cancer Research Center PO Box 10 1949 D-6900 Heidelberg 1 West Germany |
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