SYSTEMIC-ONSET JUVENILE CHRONIC ARTHRITIS AND BONE MARROW HYPOPLASIA |
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| Authors: | EWER, A. K. DARBYSHIRE, P. J. SOUTHWOOD, T. R. |
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| Affiliation: | Childhood Arthritis Unit, Department of Rheumatology, University of Birmingham Vincent Drive, Edgbaston, Birmingham B15 2TT
*Department of Haematology, The Children's Hospital Ladywood Middleway, Ladywood, Birmingham B16 8ET |
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| Abstract: | A two-and-a-half-year-old girl with systemic-onset JCA developedpancytopaenia 21 days after her illness began. Bone marrow examinationrevealed hypoplasia, with no evidence of erythrophagocytosis.Two weeks later peripheral blood specimens showed evidence ofbone marrow regeneration. No definite cause for the hypoplasiawas found subsequently. Persistent haematological abnormalitiesafter resolution of the hypoplasia included anaemia of chronicinflammation, leucocytosis and thrombocytosis. Unexplained bonemarrow hypoplasia has not previously been described in systemic-onsetJCA. KEY WORDS: Systemic-onset JCA, Bone marrow hypoplasia, Pancytopaenia, JCA, Aplastic anaemia |
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