| 不同剂量苯海拉明治疗氯氮平引起的流涎 |
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| 引用本文： | 徐鹤定,董爱珍,张婷婷,舒伟洁.不同剂量苯海拉明治疗氯氮平引起的流涎[J].中国新药与临床杂志,1997(4). |
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| 作者姓名： | 徐鹤定 董爱珍 张婷婷 舒伟洁 |
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| 作者单位： | 上海市精神卫生中心，上海市杨浦区精神卫生中心，上海第二医科大学 |
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| 摘 要： | 目的：评价不同剂量苯海拉明对氯氮平引起流涎的疗效及不良反应。方法：服用氯氮平的精神分裂症病人９０例，分为３组，每组３０例。苯海拉明５０ｍｇ／ｄ组给予苯海拉明５０ｍｇ，ｐｏ，ｑｄ×２ｗｋ。苯海拉明２５ｍｇ／ｄ组给予苯海拉明２５ｍｇ，ｐｏ，ｑｄ×２ｗｋ。对照组不增服其他药物，仅作临床观察。结果：治疗组临床总有效率与对照组比较，苯海拉明５０ｍｇ／ｄ组为９３％（Ｐ＜０．０１）；苯海拉明２５ｍｇ／ｄ组为７７％（Ｐ＜０．０１）；苯海拉明２组间疗效无显著差异（Ｐ＞０．０５）；不良反应少而轻微。结论：苯海拉明治疗氯氮平引起的流涎疗效显著且安全。
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| 关 键 词： | 苯海拉明 氯氮平 流涎 精神病学 |
Diphenhydramine for clozapine-induced salivation at various dosage levels |
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| XU He-Ding,DONG Ai-Zhen ,ZHANG Ting-Ting,SHU Wei-Jie.Diphenhydramine for clozapine-induced salivation at various dosage levels[J].Chinese Journal of New Drugs and Clinical Remedies,1997(4). |
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| Authors: | XU He-Ding DONG Ai-Zhen ZHANG Ting-Ting SHU Wei-Jie |
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| Institution: | XU He-Ding,DONG Ai-Zhen 1,ZHANG Ting-Ting,SHU Wei-Jie 2 |
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| Abstract: | AIM: To evaluate the effects and adverse reactions of diphenhydramine on clozapine-induced salivation. METHODS: Ninety patients of schizophrenics exposed to clozapine were divided into 3 groups, each containing 30 patients. Oral diphenhydramine was given daily for 2 wk to group diphenhydramine (25 mg/d) and group diphenhydramine (50 mg/d). Controlled group was for clinical observation and was not exposed to other drugs additionally. RESULTS: Compared with the controlled group, The overall clinical effective rate was 93%(P<0.01) for group diphenhydramine (50 mg/d) and 77%(P<0.01) for group diphenhydramine (25 mg/d). There was no significant difference between the effective rates of the later two groups (P>0.05). Adverse reactions were infrequent and mild. CONCLUSION: Diphenhydramine is effective and safe in the treatment of clozapine-induced salivation. |
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| Keywords: | diphenhydramine clozapine sialorrhea psychiatry |
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