| 血清胱蛋白C对早期糖尿病肾病的诊断价值 |
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| 引用本文： | 卞鲁岩,夏平. 血清胱蛋白C对早期糖尿病肾病的诊断价值[J]. 实用医药杂志(山东), 2003, 20(12): 896-897 |
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| 作者姓名： | 卞鲁岩 夏平 |
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| 作者单位： | 青岛市市立医院肾内科 山东青岛266071(卞鲁岩)，青岛市市立医院肾内科 山东青岛266071(夏平) |
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| 摘 要： | 目的寻找一种更为简便的诊断早期糖尿病肾病的方法。方法采用颗粒增强透射免疫比浊法(PENIA)测定67例糖尿病(DM)病人的血清胱蛋白C(Cysc)浓度,同时测定白蛋白排泄率(UAE)作为对照,以判断血清胱蛋白C浓度在早期糖尿病肾病中的临床意义及应用价值。结果UAE升高组(早期糖尿病肾病组)的血清Cysc浓度均较UAE正常组明显升高(P<0.01),与尿β2微球蛋白(β2-MG)浓度呈正相关,与肌酐清除率(Ccr)呈负相关。结论血清Cysc浓度升高可作为诊断早期糖尿病肾病的一项指标,它和UAE有相同的临床意义,并且简便易行。
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| 关 键 词： | 血清胱蛋白C 尿白蛋白排泄率 早期糖尿病肾病 |
| 修稿时间： | 2003-09-19 |
Significance of serum cystatin C concentration in diagnosis of early diabetic nephropathy |
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| BIAN Luyan,XIA Ping. Significance of serum cystatin C concentration in diagnosis of early diabetic nephropathy[J]. Practical Journal of Medicine & Pharmacy, 2003, 20(12): 896-897 |
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| Authors: | BIAN Luyan XIA Ping |
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| Affiliation: | BIAN Luyan,XIA Ping.Department of Kidney,Qingdao Municipal Hospital,Qingdao266071,China |
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| Abstract: | Objective To study a simple method for diagnosis of early diabetic nephropathy.Methods Serum cystatin C concentration and urinary albumin excretion(UAE)were measured in67patients with diabetes mellitus by particle-enhanced turbidimetric immunoassay.Relationship between the two parameters was evaluated.Results Serum cystatin C was positively correlated with urinary albumin excretion orβ2microglobulin,and negatively correlated with creatinine clear rate(Ccr).Conclusion Serum cystatin C is a useful indicator for diagnosis of early diabetic nephropathy,simpler and feasibler than urinary albumin excretion. |
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| Keywords: | Serum cystatin C Urinary albumin excretion Early diabetic nephropathy |
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