| L-plastin启动子单核苷酸多态性与前列腺癌遗传易感性的相关性研究 |
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| 引用本文： | 宋涛,林天歆,董文,黄健.L-plastin启动子单核苷酸多态性与前列腺癌遗传易感性的相关性研究[J].中国男科学杂志,2010,24(9). |
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| 作者姓名： | 宋涛 林天歆 董文 黄健 |
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| 作者单位： | 1. 中山大学附属博济医院泌尿外科,广州,511300
2. 中山大学附属孙逸仙纪念医院泌尿外科 |
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| 基金项目： | 国家自然科学基金面上项目，广东省自然科学基金重点项目，教育部博士点基金，广东省自然科学基金 |
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| 摘 要： | 目的 研究L-plastin启动子单核苷酸多态性(SNP)与前列腺癌的关系.方法 采用Tm-shifting(等位基因特异性扩增结合融解温度曲线分析法)分析方法,对82例前列腺癌人群和94例对照人群的L-plastin启动子SNP位点的基因型进行检测.结果 L-plastin启动子TT、CT、CC基因型及等位基因T、C在汉族前列腺癌患者及对照者中的分布频率差异无显著性(P>0.05);在前列腺癌组内不同病理分级中,中、高分化组和低分化组中TT、CT、CC基因型分布频率差异无显著性(P>0.05);在前列腺癌组内不同临床分期中,与TT纯合子相比,CC纯合子前列腺癌Ⅳ期的风险增加至5.0倍(P<0.05).结论 L-plastin启动子单核苷酸多态性在中国汉族人群中与前列腺癌无相关,但该启动子多态性可能在预测前列腺癌进展中有一定作用.
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| 关 键 词： | 前列腺肿瘤 L-plastin基因 多态性 单核苷酸 |
Studies on the relationship between single nucleotide polymorphism of L-plastin gene promoter and susceptibility to prostate cancer |
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| Song Tao,Lin Tianxin,Dong Wen,Huang Jian.Studies on the relationship between single nucleotide polymorphism of L-plastin gene promoter and susceptibility to prostate cancer[J].Chinese Journal of Andrology,2010,24(9). |
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| Authors: | Song Tao Lin Tianxin Dong Wen Huang Jian |
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| Institution: | Song Tao~1,Lin Tianxin~2,Dong Wen~2,Huang Jian~(2**) 1.Department of Urology,Boji Hospital,Sun Yet-sen University,guangzhou 511300,China,2.Department of Urology,Sun Yet-sen Memorial Hospital |
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| Abstract: | Objective To investigate the relationship between the single nucleotide polymorphism of L-plastin gene promoter and susceptibility to prostate cancer.Methods Eighty two PCa patients and ninety four age-matched controls were recruited in the study.The genotypes of single nucleotide polymorphism of L-plastin gene promoter were determined by real-time PCR based Tm-shifting method.Results There was no significant difference in the distribution of genotype and allele between PCa patients and normal controls (P>0... |
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| Keywords: | prostatic neoplasms L-plastin gene polymorphism single nucleotide |
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