新型免疫抑制剂FTY720的研究进展

FTY720是一种来源于子囊菌冬虫夏草的新型免疫抑制剂,与常规免疫抑制剂环孢素、他克莫司、西罗莫司等相比具有不同的作用机制,其主要通过致淋巴细胞凋亡及归巢效应等起到免疫抑制的作用,在多种动物模型的同种异体移植中具有抑制移植物排斥作用,在人体肾脏移植中也呈较强的免疫抑制活性,故在临床器官移植及自身免疫性疾病的治疗等方面具有广泛的应用前景.

Research Progress of Novel Immunosuppressant FTY720

FTY720 is a biosynthetic compound derived from the metabolites of Isaria sinclairii. Its unique action mechanism appears to be distinctive from other known immunosuppressive agents, such as cyclosporin A, tacrolimus and sirolimus. FTY720 can function as an immunosuppressive agent through selective induction of apoptosis of lymphocytes and effect of lymphocytes homing, which are considered to be its potency of inhibiting graft rejection in various animal allotransplantation models and effecting in human's renal transplantation. It was approved or being developed for wide uses in organ transplantation and self-immunity diseases.