慢性乙型肝炎患者血清抗Hp抗体检测及抗Hp抗体与HBV载量和HBV基因型的关系

目的：探讨幽门螺杆菌(Hp)在慢性乙型肝炎中的作用。方法：对376例慢性乙型肝炎患者 （分为肝炎组、乙型肝炎肝硬化组和并发肝癌组）的Hp感染状况与HBV DNA定量、HBV DNA分型进行检测，并与健康对照组和慢性胃炎组进行对比。 结果：慢性乙型肝炎组（56.2%）、乙型肝炎肝硬化组（69.9%）和乙型肝炎并发肝癌组（75.0%）Hp感染率明显高于健康对照组（43.4%）（P<0.01），各组与慢性胃炎组（57.9％）比较差异无显著性（P>0.05），其中肝硬化组和并发肝癌组Hp感染率均高于肝炎组（P<0.05）。不同病毒载量的慢性乙型肝炎患者的Hp感染率均明显高于健康对照组（P<0.01），但不同病毒载量之间差异无显著性（P>0.05）。B、C和D基因型慢性乙型肝炎患者Hp感染率分别为61.3%、63.3%和50.0%，3组之间比较差异无显著性（P>0.05）。结论：慢性乙型肝炎患者Hp感染率明显增加，且Hp感染率随着肝脏病变程度的进展而增加。

Relationship between anti-Hp-IgG seroprevalence and HBV load and HBV genotypes in patients with chronic hepatitis B

Objective To research the role of Helicobacter pylori(Hp) on chronic hepatitis B.Methods The seroprevalence of Hp infection and the quantity and genotyping of HBV DNA in 376 patients with chronic hepatitis B,including chronichepatitis group,cirrhosis group and HBV-related hepatocellular carcinoma(HCC) group,were detected,and compared with control and gastritis groups.Results Hp seropositivities in chronic hepatitis B group(56.2%),cirrhosis group(69.9%),HCC group(75.0%) were higher than that in control group(43.4%)(P<0.01),and had no significant difference with chronic gastritis group(57.9%)(P>0.05),the Hp seropositivities in cirrhosis and HCC groups were higher than that in chronic hepatitis group(P<0.05).With the different quantities of HBV,Hp seropositivities all increased compared with control group(P<0.01);but there was no significant difference between the different quantities of virus.Hp seropositivities in chronic hepatitis patients with genotype B,C and D were 61.3%,63.3%,and 50.0%,respectively,but there was no significant difference between patients with different HBV genotypes(P>0.05).Conclusion Seroprevalence of antibodies to Hp in patients with chronic hepatitis B increases significantly,and Hp seropositivity increases with the pathological changes of chronic hepatitis B.