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| 丙基硫氧嘧啶致儿童继发性抗中性粒细胞胞浆抗体相关小血管炎1例报告并文献复习 | |
| 引用本文： | 史卓,樊忠民,夏正坤,高远赋,孙涛,黄倩,任献国,张沛. 丙基硫氧嘧啶致儿童继发性抗中性粒细胞胞浆抗体相关小血管炎1例报告并文献复习[J]. 临床儿科杂志, 2012, 30(4): 316-318 |
| 作者姓名： | 史卓 樊忠民 夏正坤 高远赋 孙涛 黄倩 任献国 张沛 |
| 作者单位： | 南京军区南京总医院儿科,江苏南京,210002 |
| 摘 要： | 目的分析丙基硫氧嘧啶(PTU)致抗中性粒细胞胞浆抗体(ANCA)相关小血管炎的临床及机制。方法报道1例长期服用PTU患儿所致ANCA相关小血管炎,并复习近年来相关文献报道。结果患儿因贫血、蛋白尿、肾功能不全,伴咯血就诊,追问病史发现其发病前曾服用PTU 3年。经免疫抑制、血液净化,以及停用PTU后,患儿症状缓解,肾功能改善。结论 PTU可引起ANCA相关性血管炎,及时停用相关药物以及应用免疫抑制剂、血液净化等治疗,可使病情缓解。 |
| 关 键 词： | 肾功能不全 丙基硫氧嘧啶 血管炎 抗中性粒细胞胞浆抗体 儿童 |
Propylthiouracil-associated antineutrophil cytoplasmic antibody-positive vasculitis: a case report and literature review |
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| SHI Zuo , FAN Zhong-min , XIA Zheng-kun , GAO Yuan-fu , SUN Tao , HUANG Qian , REN Xian-guo , ZHANG Pei. Propylthiouracil-associated antineutrophil cytoplasmic antibody-positive vasculitis: a case report and literature review[J]. The Journal of Clinical Pediatrics, 2012, 30(4): 316-318 | |
| Authors: | SHI Zuo FAN Zhong-min XIA Zheng-kun GAO Yuan-fu SUN Tao HUANG Qian REN Xian-guo ZHANG Pei |
| Affiliation: | (Department of Pediatrics,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China) |
| Abstract: | objective To explore the mechanism of propylthiouracil(PTU)induced anti-neutrophil cytoplasmic antibody(ANAC)associated vasculitis.Methods One case of PTU induced ANAC-positive vasculitis was reported.Relevant literatures were reviewed.Results The patient presented with anemia,proteinuria,renal function damage,and ANAC-positive.The patient had oral administration of PTU for 3 years.The symptom was relieved and the renal function was improved after treatment by immunosuppression,blood purification,as well as withdraws of PTU.Conclusions PTU may induce ANAC-positive vasculitis.Withdraw of PTU and treatment by immunosuppression and blood purification can remiss the disease. |
| Keywords: | renal insufficiency propylthiouracil vasculitis antineutrophil cytoplasmic antiboby child |
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