| 维生素D的免疫调节作用与儿童疾病 |
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| 引用本文： | 李海园,刘志伟.维生素D的免疫调节作用与儿童疾病[J].临床儿科杂志,2012,30(8):792-794. |
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| 作者姓名： | 李海园 刘志伟 |
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| 作者单位： | 上海交通大学附属国际和平妇幼保健院 上海 200030 |
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| 基金项目： | 上海市自然科学基金资助项目 |
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| 摘 要： | 维生素D不仅参与钙磷代谢,而且还是一类重要的免疫功能调节剂。维生素D主要通过调节各种免疫细胞的生长、分化和功能,影响细胞因子和抗微生物肽的分泌,在固有性免疫和适应性免疫中发挥重要作用。研究发现,维生素D缺乏与儿科急性下呼吸道感染、糖尿病和哮喘等疾病的发生发展相关。文章就维生素D的免疫调节作用及其与儿童疾病的相关性作一综述。
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| 关 键 词： | 维生素D Toll样受体 巨噬细胞 树突状细胞 调节性T细胞 |
Immunomodulating effect of vitamin D and children's diseases |
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| LI Hai-yuan.Immunomodulating effect of vitamin D and children's diseases[J].The Journal of Clinical Pediatrics,2012,30(8):792-794. |
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| Authors: | LI Hai-yuan |
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| Institution: | (The International Peace Maternity and Child Health Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200030,China) |
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| Abstract: | Vitamin D,participating in calcium and phosphorus metabolism,is an important functional immune regulator.Vitamin D plays an important role in modulating both innate and adaptive immune responses,mainly through the modulation of growth,differentiation and function of a variety of immune cells,and the influence of secretion of cytokines and antimicrobial peptides.Studies show a close association between vitamin D deficiency and pediatric diseases such as acute lower respiratory infection,diabetes and asthma.The purpose of this paper is to review immunomodulating effect of vitamin D and the correlation between vitamin D and children’s diseases. |
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| Keywords: | vitamin D toll-like receptor macrophage dendritic cells regulatory T cells |
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