Protective effects of MCP-1 inhibitor on a rat model of severe acute pancreatitis |
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| Authors: | Guo-Xiong Zhou Xue-Juan Zhu Xiao-Ling Ding Hong Zhang Jian-Ping Chen Hui Qiang Hai-Feng Zhang Qun Wei Nantong China |
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| Affiliation: | Guo-Xiong Zhou,Xue-Juan Zhu,Xiao-Ling Ding,Hong Zhang,Jian-Ping Chen,Hui Qiang,Hai-Feng Zhang , Qun Wei Nantong,China Department of Gastroenterology,Affiliated Hospital of Nantong University,Nantong 226001,China |
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| Abstract: | BACKGROUND:Chemokines and their receptors play key roles in the pathogenesis of acute pancreatitis.This study aimed to establish a rat model of severe acute pancreatitis(SAP) for investigating monocyte chemotactic protein-1(MCP-1) expression in the pathogenesis of the disease.We assessed the effects of the inhibitor of MCP-1,Bindarit,on SAP and explored the mechanisms underlying SAP. METHODS:Seventy-two Sprague-Dawley rats were randomly divided into a saline control group(group S),an SAP group (group P),and... |
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| Keywords: | severe acute pancreatitis monocyte chemotactic protein-1 Bindarit pathogenesis |
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