Impact of antibiotic resistance on the treatment of gram-negative sepsis |
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| Authors: | Lindsey R. Baden MD Barry I. Eisenstein MD |
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| Affiliation: | (1) Division of Infectious Disease, Brigham and Women’s Hospital, and Harvard Medical School, PBB-A4, 15 Francis Street, 02115 Boston, MA, USA;(2) Beth Israel Deaconess Medical Center and Harvard Medical School, 02115 Boston, MA, USA |
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| Abstract: | Resistance among gram-negative organisms has greatly complicated the care of the septic patient. An understanding of the likely source of infection, the epidemiologic risk of the patient being exposed to an antibiotic-resistant organism, and the specific vulnerabilities of the host are essential to the proper selection of empiric antimicrobial therapy. In this report, we discuss the epidemiology, antibiotic resistance mechanisms, microbiology, treatment strategies, and diagnostic and therapeutic innovations in the approach to the septic patient. |
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