Transfusion of Fresh Platelet Concentrates to Adult Patients with Thrombocytopenia |
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| Authors: | J. A. Cavins M.D. S. Farber A. J. Roy |
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| Affiliation: | Children's Cancer Research Foundation, Children's Hospital Medical Center, Boston, Massachusetts;Research Associate, Children's Cancer Research Foundation and Department of Pathology, Harvard Medical School.;Director of Research, The Children's Cancer Research Foundation and Professor of Pathology, Harvard Medical School at the Children's Hospital Medical Center.;Research Assistant in Pathology, Children's Cancer Research Foundation and Children's Hospital Medical Center. |
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| Abstract: | Fresh platelet concentrates were given to 18 adult patients on 68 occasions without adverse effect. The concentrates were prepared by means of a closed-system plateletpheresis technic which permitted rapid and frequent bleeding of donors. There was a direct relationship of the amount of platelets infused to the mean posttransfusion increment. Excellent hemostatic effect was noted in 84% of patients with active bleeding when the platelet increment was 40,000/mm3 or better. Transfusion of large numbers of platelet concentrates is effective in controlling or averting bleeding in adults with thrombocytopenia and is recommended on a therapeutic and prophylactic basis. |
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