Effects of cytotoxins on intracellular Na/K balance in mouse embryonic cell |
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| Authors: | A. G. Pogorelov D. V. Goldshtein V. N. Pogorelova |
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| Affiliation: | (1) Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia;(2) Pushchino State University, Pushchino, Russia;(3) Medical Genetic Research Center, Russian Academy of Medical Sciences, Moscow, Russia;(4) ReMeTex Company, Moscow, Russia |
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| Abstract: | Cytoplasmic Na/K imbalance induced by cytotoxic substances (ethylene glycol and cytochalasin B) was studied. Incubation in Dulbecco’s medium with these cytotoxins caused changes in K and Na concentrations in the mouse two-cell embryo blastomer. The effects of both substances resulted in a drop of Na content in the embryonic cell. Washing from cytochalasin B restored the initial Na/K balance in the cytoplasm. Possible adaptive mechanisms involved in the regulation of intracellular ionic homeostasis are discussed. __________ Translated from Kletochnye Tehnologii v Biologii i Meditsine, No. 2, pp. 102–105, April, 2008 |
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| Keywords: | mouse embryonic cell cytochalasin B ethylene glycol cytoplasmic Na/K balance electron probe microanalysis |
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