| 藏药唐古特青兰耐缺氧和清除氧自由基作用的实验研究 |
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| 引用本文： | 叶于聪,陈钦铭,柴凤玲,海平,周生祥. 藏药唐古特青兰耐缺氧和清除氧自由基作用的实验研究[J]. 中草药, 1994, 0(3): 134-136 |
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| 作者姓名： | 叶于聪 陈钦铭 柴凤玲 海平 周生祥 |
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| 作者单位： | 青海省高原医学科学研究所!西宁810012 |
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| 摘 要： | 唐古特青兰水提液灌胃或腹腔注射，通过小鼠密闭缺氧和减压缺氧实验，表明有耐缺氧作用；在特高海拔4700m地区取样测定大小鼠红细胞SOD活性，提示有提高机体歧化过氧阴离子能力；模拟海拔6000m实验条件，测定小鼠肝脏脂质过氧化产物MDA，血红蛋白、血球压积，显示有抗肝脏脂质过氧化作用，降低异常增高的血红蛋白和血球压积作用。提示唐古特青兰耐缺氧作用部分是通过抗氧自由基引起的。
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| 关 键 词： | 唐古特青兰 闭密缺氧 减压缺氧 超氧化物歧化酶 过氧化脂质 |
| 收稿时间： | 1993-02-22 |
Studies on the Antihypoxia and Free Radical Scavenging Activity of Tangut Dragonhead |
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| Ye Yucong,Chen Qinming,Chai Fengling,Hai Ping and Zhou Shengxiang. Studies on the Antihypoxia and Free Radical Scavenging Activity of Tangut Dragonhead[J]. Chinese Traditional and Herbal Drugs, 1994, 0(3): 134-136 |
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| Authors: | Ye Yucong Chen Qinming Chai Fengling Hai Ping Zhou Shengxiang |
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| Affiliation: | Qinghai Provincial Institute of High Altitude Medical Sciences, Xining;Qinghai Provincial Institute of High Altitude Medical Sciences, Xining;Qinghai Provincial Institute of High Altitude Medical Sciences, Xining;Qinghai Provincial Institute of High Altitude Medical Sciences, Xining;Qinghai Provincial Institute of High Altitude Medical Sciences, Xining |
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| Abstract: | Aqueous extract of Dracocephalum tanguticum Maxim. (DtM), when given ig or ip to experimental hypoxia mice,markedly increased their tolerance to normobaric and hypobaric hypoxia. Erythrocyte superoxide dismutasc (SOD) activity of mice or rats determined at high altitude (animaquing mountain 4700 m above sea level) showed an elevated dismutation activity of peroxide anions. At an experimentally simulatcd altitude of 6000 m above sea level,determunation of MDA, Hb and Hct showed an obvious reduction of all the abnormally elevated criteria. It is suggested that the antihypoxia activity of DTM may be partly due to its free radical scavenging activity. |
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