|
|||||
|
|
Clinical and pathological impact of an optimal assessment of brain invasion for grade 2 meningioma diagnosis: lessons from a series of 291 cases |
|
| Authors: | Picart Thiébaud Dumot Chloé Guyotat Jacques Pavlov Vladislav Streichenberger Nathalie Vasiljevic Alexandre Fenouil Tanguy Durand Anne Jouanneau Emmanuel Ducray François Jacquesson Timothée Berhouma Moncef Meyronet David |
| Affiliation: | 1.Department of Neurosurgery, H?pital Neurologique Pierre Wertheimer, 59 Boulevard Pinel, 69667, Hospices Civils de Lyon, Bron, France ;2.Claude Bernard University, Lyon 1, Lyon, France ;3.Department of Cancer Cell Plasticity – INSERM U1052, Cancer Research Center of Lyon, Lyon, France ;4.CarMeN Laboratory, Inserm U1060, INRA U1397, INSA Lyon, Université Claude Bernard, Lyon 1, Lyon, France ;5.Department of Neuropathology, Groupe Hospitalier Est, Hospices Civils de Lyon, Bron, France ;6.CNRS UMR 5310 – INSERM U1217, Institut NeuroMyogène, Lyon, France ;7.Department of Neurosurgery, Medipole Lyon Villeurbanne MHP, Villeurbanne, France ;8.CNRS UMR5286, Inserm U1052, Cancer Research Center of Lyon, Lyon, France ;9.Department of Neurooncology, H?pital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France ;10.Laboratory of Anatomy, Faculty of Medicine Lyon Est, University Claude Bernard Lyon 1, Lyon, France ;11.CREATIS Laboratory, Inserm U1206, UMR 5220, Université de Lyon, Villeurbanne, France ; |
| Abstract: | Brain invasion has not been recognized as a standalone criterion for atypical meningioma by the WHO classification until 2016. Since the 2007 edition suggested that meningiomas harboring brain invasion could be classified as grade 2, brain invasion study was progressively strengthened in our center, based on a strong collaboration between neurosurgeons and neuropathologists regarding sample orientation and examination. Practice changes were considered homogeneous enough in 2011. The aim of the present study was to evaluate the impact of gross practice change on the clinical and pathological characteristics of intracranial meningiomas classified as grade 2. The characteristics of consecutive patients with a grade 2 meningioma surgically managed before (1998–2005, n?=?125, group A) and after (2011–2014, n?=?166, group B) practices changed were retrospectively reviewed. Sociodemographical and clinical parameters were comparable in groups A and B, and the median age was 62 years in both groups (p?=?0.18). The 5-year recurrence rates (23.2% vs 29.5%, p?=?0.23) were similar. In group A, brain invasion was present in 48/125 (38.4%) cases and was more frequent than in group B (14/166, 8.4%, p?SBI), and 92 harbored other grade 2 criteria (group AOCA). Group ASBI meningiomas had a similar median progression-free survival compared to groups AOCA (68 vs 80 months, p?=?0.24) and to AOCA and B pooled together (n?=?258, 68 vs 90 months, p?=?0.42). An accurate assessment of brain invasion is mandatory as brain invasion is a strong predictor of meningioma progression. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |