老年2型糖尿病患者骨质疏松与肌少症的相关性

目的 探讨老年2型糖尿病(T2DM)患者骨质疏松与肌少症的相关性.方法 选择2017年5月至2019年7月于首都医科大学宣武医院内分泌科住院的579例年龄≥60岁的T2DM患者为研究对象,测量患者腰椎、左股骨颈及左全髋骨密度(BMD);测量糖化血红蛋白(HbA1c)、握力与步速、四肢骨骼肌质量( ASM),计算四肢骨骼...

Correlation between osteoporosis and sarcopenia in elderly patients with type 2 diabetes mellitus

Objective To investigate the correlation between osteoporosis and sarcopenia in elderly patients with type 2 diabetes mellitus(T2DM).Methods Totally 579 patients aged≥60 years with T2DM were enrolled from the Department of Endocrinology of Xuanwu Hospital.Bone mineral density(BMD)of lumbar vertebrae,left femoral neck and left total hip were measured.Hemoglobin A1c(HbA1c),appendicular skeletal muscle mass(ASM),grip strength and walking speed were also measured.The appendicular skeletal muscle mass index(ASMI)was calculated.The participants were divided into two groups according to osteoporosis and sarcopenia,with 180 cases in osteoporosis group and 399 cases in nonosteoporosis group,52 cases in sarcopenia group and 527 cases in nonsarcopenia group.The correlation between osteoporosis and sarcopenia was assessed.SPSS 24.0 was used for data analysis.According to the different data type,t-test,Mann-Whitney U test orχ² test was used for comparison between groups.Multivariate logistic regression was used to analyze the association between sarcopenia and osteoporosis.Results Body mass index(BMI),BMD and T values of left femoral neck,left total hip in the sarcopenia group were significantly lower than those in the nonsarcopenia group(P<0.05).BMI,ASMI,grip strength and walking speed in the osteoporosis group were significantly lower than those in the nonosteoporosis group(P<0.05).Multiple logistic regression analysis showed that sarcopenia was a risk factor for osteoporosis(OR=2.16,95%CI 1.131-4.125,P=0.02)and that osteoporosis was a risk factor for sarcopenia(OR=2.27,95%CI 1.121-4.596,P=0.023)in old adults with T2DM.Conclusion Osteoporosis and sarcopenia can interplay each other in the elderly patients with T2DM.